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ITGA6 and PXN
Number of citations of the paper that reports this interaction (PMID
12033289
)
3
Data Source:
HPRD
(in vivo)
ITGA6
PXN
Gene Name
integrin, alpha 6
paxillin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Basement Membrane
Plasma Membrane
Cell-cell Adherens Junction
Focal Adhesion
External Side Of Plasma Membrane
Basal Plasma Membrane
Cell Surface
Hemidesmosome
Filopodium
Integrin Alpha6-beta4 Complex
Stress Fiber
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
Focal Adhesion
Cell Cortex
Lamellipodium
Molecular Function
Integrin Binding
Protein Binding
Laminin Binding
Metal Ion Binding
Integrin Binding
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Vinculin Binding
Protein Kinase Binding
BH4 Domain Binding
Biological Process
Cell-substrate Junction Assembly
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Blood Coagulation
Ectodermal Cell Differentiation
Positive Regulation Of Cell-substrate Adhesion
Single Organismal Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Extracellular Matrix Organization
Hemidesmosome Assembly
Cell-substrate Adhesion
Cellular Response To Extracellular Stimulus
Cell Adhesion Mediated By Integrin
Cell Junction Assembly
Nail Development
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Skin Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Filopodium Assembly
Digestive Tract Development
Brown Fat Cell Differentiation
Leukocyte Migration
Cellular Response To Organic Cyclic Compound
Renal System Development
Amelogenesis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Activation Of MAPK Activity
Movement Of Cell Or Subcellular Component
Muscle Contraction
Cytoskeleton Organization
Cell Adhesion
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Lamellipodium Assembly
Cell Junction Assembly
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Branching Morphogenesis Of An Epithelial Tube
Growth Hormone Receptor Signaling Pathway
Pathways
Cell junction organization
Syndecan interactions
Type I hemidesmosome assembly
Collagen formation
Laminin interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
Assembly of collagen fibrils and other multimeric structures
Basigin interactions
Cell surface interactions at the vascular wall
Cell junction organization
GAB1 signalosome
Smooth Muscle Contraction
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by EGFRvIII in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
VEGFA-VEGFR2 Pathway
Signaling by EGFR
Signaling by VEGF
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Signaling by EGFR in Cancer
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Prostate cancer (
19767753
)
Protein-Protein Interactions
21 interactors:
ADAM9
APP
BIN1
CALM1
CANX
CD151
CD36
CD63
CD82
COL17A1
GIPC1
GRB2
ITGB1
ITGB4
PCSK5
PLEC
PRKCD
PXN
RABIF
RPSA
TSPAN4
73 interactors:
ABL1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGB1
ITGB3
LCK
LIMK1
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RNF5
SDC4
SELE
SORBS1
SRC
SYK
TLN1
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
XPO1
Entrez ID
3655
5829
HPRD ID
00945
03937
Ensembl ID
ENSG00000091409
ENSG00000089159
Uniprot IDs
P23229
E7EMK8
F5GZ78
P49023
PDB IDs
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3C
3U3F
4EDN
Enriched GO Terms of Interacting Partners
?
Hemidesmosome Assembly
Cell-substrate Junction Assembly
Cell Activation
Cell-matrix Adhesion
Cell Junction Assembly
Cell Adhesion
Platelet Activation
Cell-substrate Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Blood Coagulation
Hemostasis
Response To Wounding
Cellular Component Assembly
Secretion By Cell
Regulation Of Body Fluid Levels
Platelet Degranulation
Response To Growth Factor
Wound Healing
Secretion
Positive Regulation Of Endocytosis
Positive Regulation Of Transport
Integrin-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cellular Response To Growth Factor Stimulus
Regulation Of MAPK Cascade
Protein Transport
Epidermal Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Endocytosis
Vesicle-mediated Transport
Establishment Of Protein Localization
Regulation Of Endocytosis
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Movement Of Cell Or Subcellular Component
Establishment Of Localization In Cell
Regulation Of Protein Phosphorylation
Cell-cell Adhesion Mediated By Integrin
Response To Oxidative Stress
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Transport
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
Locomotion
Movement Of Cell Or Subcellular Component
Regulation Of Cell Adhesion
Cell Morphogenesis Involved In Differentiation
Response To Wounding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Wound Healing
Blood Coagulation
Regulation Of Phosphorylation
Hemostasis
Cell Migration
Response To External Stimulus
Cell Projection Morphogenesis
Axonogenesis
Cell Part Morphogenesis
Cell Morphogenesis
Immune System Process
Immune Response-regulating Signaling Pathway
Neuron Projection Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Motility
Positive Regulation Of Catalytic Activity
Axon Development
Anatomical Structure Morphogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Cell Projection Organization
Regulation Of Phosphorus Metabolic Process
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Phosphorylation
Regulation Of Protein Phosphorylation
Chemotaxis
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Catalytic Activity
Regulation Of Kinase Activity
Neuron Projection Development
Response To Stress
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Cell-substrate Adhesion
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?