ITGA6 and CD151

Number of citations of the paper that reports this interaction (PubMedID 10811835)
79

Data Source:
HPRD (in vivo)

		ITGA6	CD151
Description		integrin subunit alpha 6	CD151 molecule (Raph blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha6-beta1 Complex Integrin Alpha6-beta4 Complex	Basement Membrane Cytosol Plasma Membrane Focal Adhesion Cell Surface Membrane
	Molecular Function	Protein Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Cadherin Binding Metal Ion Binding	Integrin Binding Protein Binding
	Biological Process	Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Migration Cell-substrate Adhesion Nail Development Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Adhesion Cell Migration Positive Regulation Of Cell Migration T Cell Proliferation Wound Healing, Spreading Of Cells Positive Regulation Of Endocytosis
Pathways		Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Nephropathy with pretibial epidermolysis bullosa and deafness
GWAS		Alzheimer's disease biomarkers ( 23419831) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 19767753 31562322)	Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)
Interacting Genes		23 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4 USP40	12 interacting genes: ARL13B BCL7A GRAMD1C ITGA3 ITGA6 ITGB1 KLRC1 MMP7 PTGFRN RNF128 TMEM139 TSPAN18
Entrez ID		3655	977
HPRD ID		00945	03763
Ensembl ID		ENSG00000091409	ENSG00000177697
Uniprot IDs		A0A8C8KBL6 A0AAQ5BID9 P23229	P48509 Q6ZNZ0
PDB IDs		7CEB 7CEC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Integrin Binding Cell-substrate Adhesion Hemidesmosome Assembly Hemidesmosome Cell-matrix Adhesion Extracellular Exosome Focal Adhesion Cell Migration Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Endocytosis Plasma Membrane Laminin Binding Membrane Cell Motility Positive Regulation Of Transport Regulation Of Superoxide Metabolic Process Cell Adhesion Mediated By Integrin Vesicle-mediated Transport Low-density Lipoprotein Particle Mediated Signaling Import Into Cell Cell Surface Cell-substrate Junction Assembly Cell-substrate Junction Organization Regulation Of Spontaneous Synaptic Transmission Presynaptic Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Action Potential Cellular Response To Hydroperoxide Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Leukocyte Activation Receptor-mediated Endocytosis Vesicle Regulation Of Transport Receptor Internalization Receptor Complex Regulation Of Supramolecular Fiber Organization Insulin Receptor Substrate Binding Cell-cell Junction Response To Manganese Ion Anchoring Junction Cell Activation Mesodermal Cell Differentiation Endothelial Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Biological Quality	Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Complex Formation Of Radial Glial Scaffolds Cell-matrix Adhesion Integrin-mediated Signaling Pathway Mesodermal Cell Differentiation Laminin Binding Negative Regulation Of Rho Protein Signal Transduction Cell-substrate Adhesion Myoblast Fusion Fibronectin Binding Receptor Complex Syncytium Formation By Plasma Membrane Fusion Cell-cell Fusion Syncytium Formation Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Integrin Alpha6-beta4 Complex Myoblast Fate Specification Integrin Alpha7-beta1 Complex Inhibitory MHC Class Ib Receptor Activity Antibacterial Peptide Secretion Signaling Receptor Activity Cell Surface Negative Regulation Of Small GTPase Mediated Signal Transduction Synaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha9-beta1 Complex HLA-E Specific Inhibitory MHC Class Ib Receptor Activity External Side Of Plasma Membrane Positive Regulation Of GTPase Activity Growth Cone Filopodium Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Localization To Membrane Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation
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