CANX and ITGB1

Number of citations of the paper that reports this interaction (PMID 8163531)
18

Data Source:
HPRD (in vivo, in vitro)

		CANX	ITGB1
Gene Name		calnexin	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Acrosomal Vesicle Ruffle Basement Membrane Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Hemidesmosome Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Recycling Endosome Extracellular Vesicular Exosome Invadopodium Membrane Synaptic Membrane
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Virus Receptor Activity Glycoprotein Binding Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Peptide Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Alpha-actinin Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Cell Fate Specification Tissue Homeostasis Cell Migration Involved In Sprouting Angiogenesis Cellular Calcium Ion Homeostasis Cellular Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Response To Virus Regulation Of Collagen Catabolic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Activity Viral Process Cell Migration Formation Of Radial Glial Scaffolds B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Projection Organization Cell-substrate Adhesion Protein Transport Within Lipid Bilayer Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Cell Junction Assembly Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Response To Drug Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAPK Cascade Sarcomere Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Maternal Process Involved In Female Pregnancy Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Vitamin D Cellular Response To Ionizing Radiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Platelet Adhesion to exposed collagen Axon guidance Elastic fibre formation L1CAM interactions Molecules associated with elastic fibres Laminin interactions ECM proteoglycans Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell junction organization Signal transduction by L1 Semaphorin interactions Other semaphorin interactions Non-integrin membrane-ECM interactions Basigin interactions Cell surface interactions at the vascular wall Syndecan interactions CHL1 interactions Integrin cell surface interactions Cell-extracellular matrix interactions Adaptive Immune System
Drugs		Antihemophilic Factor Tenecteplase
Diseases
GWAS			Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	67 interactors: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EPS8 FBLN1 FBXO2 FHL2 FLNA FLNB FLT4 FN1 GNB2L1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 NCKIPSD NF2 NME1 NMRK2 PDHB PLAUR PRKCA PRKCE PTK2 PXN RAB25 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		821	3688
HPRD ID		00252	00628
Ensembl ID		ENSG00000127022	ENSG00000150093
Uniprot IDs		P27824	P05556
PDB IDs			1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell-matrix Adhesion Cell-substrate Adhesion Wound Healing Response To Wounding Regulation Of Body Fluid Levels Multicellular Organismal Development Movement Of Cell Or Subcellular Component Anatomical Structure Development Locomotion System Development Developmental Process Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Cell Migration Leukocyte Migration Cell Motility Signal Transduction Cell Junction Assembly Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Signaling Response To Stimulus Positive Regulation Of Locomotion Regulation Of Cell Motility Cell Communication Cell Activation Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Platelet Activation Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Phosphorus Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Process Cell Morphogenesis Response To Stress
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting killed leucocyte lewis luciferase micrornas mir nfatc1 osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr
Tagcloud (Intersection) ?