CANX and IFNGR1

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		CANX	IFNGR1
Name		calnexin	interferon gamma receptor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Plasma Membrane Membrane
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Microglial Cell Activation Immune System Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Type III Interferon-mediated Signaling Pathway Astrocyte Activation Defense Response To Virus Type II Interferon-mediated Signaling Pathway Defense Response To Other Organism Cellular Response To Virus Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Interferon gamma-1b
Diseases		None	Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Daytime sleep phenotypes ( 27126917 ) Lymphocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Resting heart rate ( 24680774 ) White blood cell count ( 27863252 32888494 )	Behcet's disease ( 33393726 ) BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Cognitive performance (processing speed) ( 31598132 )
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	15 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SOCS1 STAT1 STIM1 TMEM100 TMEM237
Entrez ID		821	3459
HPRD ID		00252	00127
Ensembl ID		ENSG00000127022	ENSG00000027697
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	A0A0S2Z3Y2 A0A2R8Y4U4 A0A2R8YFL3 P15260
PDB IDs		Not available	1FG9 1FYH 1JRH 6E3K 6E3L
GO Terms Enriched among Interactors		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	Type II Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Microglial Cell Activation Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Myeloid Leukocyte Activation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Regulation Of Epithelial Cell Differentiation Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Response To Virus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Macrophage Activation Regulation Of Peptide Hormone Secretion Regulation Of Cell Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Interleukin-23 Production Growth Hormone Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Alpha-beta T Cell Activation Peptide Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Myeloid Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Hormone Secretion Cell Differentiation Positive Regulation Of MHC Class II Biosynthetic Process