CANX and IFNGR1

Number of citations of the paper that reports this interaction (PMID 8136357)
15

Data Source:
HPRD (in vivo)

		CANX	IFNGR1
Gene Name		calnexin	interferon gamma receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Dendrite Vesicle
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Signal Transduction Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		Antihemophilic Factor Tenecteplase	Interferon gamma-1b
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	10 interactors: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1 STAT4
Entrez ID		821	3459
HPRD ID		00252	00127
Ensembl ID		ENSG00000127022	ENSG00000027697
Uniprot IDs		P27824	B4DFT7 F5H5M7 P15260
PDB IDs			1FG9 1FYH 1JRH
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Response To Interferon-gamma Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Innate Immune Response Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process JAK-STAT Cascade Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Type I Interferon Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Response To Growth Hormone Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Signaling Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of JAK-STAT Cascade Cellular Response To Peptide Response To Stress Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Migration Cell Motility
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?