CANX and CD1D

Number of citations of the paper that reports this interaction (PMID 12239218)
24

Data Source:
HPRD (in vivo)

		CANX	CD1D
Gene Name		calnexin	CD1d molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cytoplasm Lysosomal Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Receptor Activity Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Histone Binding Cell Adhesion Molecule Binding Lipopeptide Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Viral Process Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Antihemophilic Factor Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	7 interactors: B2M CALR CANX CD74 P4HB PTPRC TRB
Entrez ID		821	912
HPRD ID		00252	01780
Ensembl ID		ENSG00000127022	ENSG00000158473
Uniprot IDs		P27824	P15813
PDB IDs			1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Protein Folding Antigen Processing And Presentation Of Peptide Antigen Chaperone-mediated Protein Folding Antigen Processing And Presentation T Cell Differentiation In Thymus Positive Thymic T Cell Selection Negative Thymic T Cell Selection Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Negative T Cell Selection Thymic T Cell Selection Positive T Cell Selection Lymphocyte Differentiation Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Immune System Process Positive Regulation Of B Cell Proliferation Cellular Protein Metabolic Process Leukocyte Cell-cell Adhesion T Cell Selection Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Lymphocyte Activation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Immune System Process Positive Regulation Of B Cell Activation Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Homeostatic Process Leukocyte Activation Positive Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Differentiation Regulation Of Apoptotic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Migration Single Organismal Cell-cell Adhesion Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Differentiation
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts
Tagcloud (Intersection) ?