CANX and PRKCSH

Number of citations of the paper that reports this interaction (PMID 8910335)
44

Data Source:
HPRD (in vivo, in vitro)

		CANX	PRKCSH
Gene Name		calnexin	protein kinase C substrate 80K-H
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Intracellular Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Protein Kinase C Binding Calcium Ion Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Protein Folding N-glycan Processing Protein N-linked Glycosylation Via Asparagine Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs		Antihemophilic Factor Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	9 interactors: ARL4D CANX GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		821	5589
HPRD ID		00252	03518
Ensembl ID		ENSG00000127022	ENSG00000130175
Uniprot IDs		P27824	K7ELL7 P14314
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	T Cell Differentiation In Thymus T Cell Proliferation Protein N-linked Glycosylation Via Asparagine Vitamin D Receptor Signaling Pathway Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Lymphocyte Proliferation Mononuclear Cell Proliferation Protein N-linked Glycosylation Cellular Localization Leukocyte Proliferation Protein Secretion Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Secretion Establishment Of Protein Localization T Cell Differentiation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Activation-induced Cell Death Of T Cells Regulation Of Adrenergic Receptor Signaling Pathway Oogenesis Stage Negative Regulation Of T Cell Mediated Cytotoxicity Placenta Development Mammary Gland Branching Involved In Pregnancy Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Cardiac Muscle Contraction Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glycoside Catabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Post-translational Protein Modification Multicellular Organismal Reproductive Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Multicellular Organism Reproduction Protein Insertion Into ER Membrane Negative Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Chemical Homeostasis Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Proliferation Involved In Immune Response Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Relaxation Of Vascular Smooth Muscle Regulation Of Isotype Switching To IgG Isotypes
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Intersection) ?