CANX and CD3D

Number of citations: 0 (PubMedID 8278814)
Data Source: HPRD (in vitro, in vivo)

		CANX	CD3D
Name		calnexin	CD3 delta subunit of T-cell receptor complex
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Muromonab Blinatumomab Teclistamab Odronextamab
Diseases		None	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Daytime sleep phenotypes ( 27126917 ) Lymphocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Resting heart rate ( 24680774 ) White blood cell count ( 27863252 32888494 )	Pulse pressure ( 27841878 )
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB
Entrez ID		821	915
HPRD ID		00252	01730
Ensembl ID		ENSG00000127022	ENSG00000167286
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	B0YIY4 P04234
PDB IDs		Not available	1XIW 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
GO Terms Enriched among Interactors		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Tumor Cell Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target T Cell Mediated Immunity Immune Response-activating Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Lymphocyte Activation Immune Response To Tumor Cell Membrane Leukocyte Activation Positive Thymic T Cell Selection T Cell Receptor Binding Alpha-beta T Cell Activation Positive T Cell Selection Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Immune Response Lymphocyte Mediated Immunity MHC Class I Protein Binding T Cell Mediated Cytotoxicity Immune System Process Thymic T Cell Selection Protein-containing Complex Assembly Endoplasmic Reticulum Quality Control Compartment Leukocyte Mediated Immunity Protein-containing Complex Organization T Cell Selection Protein Targeting To ER Clathrin-dependent Endocytosis Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Immune Response Synaptic Vesicle Endocytosis Positive Regulation Of Immune System Process Presynaptic Endocytosis Transmembrane Signaling Receptor Activity Plasma Membrane Protein Complex Oligomerization