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APC and YWHAQ
Number of citations of the paper that reports this interaction (PMID
15161933
)
63
Data Source:
BioGRID
(pull down)
APC
YWHAQ
Gene Name
adenomatous polyposis coli
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Image
Gene Ontology Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Microtubule
Plasma Membrane
Cell-cell Adherens Junction
Tight Junction
Lateral Plasma Membrane
Lamellipodium
Beta-catenin Destruction Complex
Ruffle Membrane
Microtubule Plus-end
Axonal Growth Cone
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Protein Binding
Protein Domain Specific Binding
Protein N-terminus Binding
Biological Process
Mitotic Cytokinesis
Kidney Development
Hair Follicle Development
Protein Complex Assembly
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Cell Cycle Arrest
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint
Cell Adhesion
Axonogenesis
Negative Regulation Of Cell Proliferation
Axis Specification
Anterior/posterior Pattern Specification
Dorsal/ventral Pattern Formation
Proximal/distal Pattern Formation
Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
T Cell Differentiation In Thymus
Somatic Stem Cell Maintenance
Negative Regulation Of Odontogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Osteoblast Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Adhesion
Muscle Cell Cellular Homeostasis
Thymus Development
Regulation Of Nitrogen Compound Metabolic Process
Chromosome Organization
Positive Regulation Of Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Retina Development In Camera-type Eye
Canonical Wnt Signaling Pathway
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Tight Junction Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Protein Targeting
Apoptotic Process
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
Programmed Cell Death
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
Apoptotic cleavage of cellular proteins
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Apoptotic execution phase
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Activation of BAD and translocation to mitochondria
Programmed Cell Death
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Heart rate variability traits (
22174390
)
Protein-Protein Interactions
109 interactors:
ACTN1
AGFG1
ANKRD17
ANXA7
AP2B1
ARHGEF4
AXIN1
AXIN2
BUB1
BUB1B
C4A
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CSNK2A1
CTBP1
CTNNA1
CTNNB1
CYTH2
DLG3
DLGAP1
DST
EPAS1
ERBB2IP
EXPH5
FAM214A
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HSPA5
HTRA2
ING5
IQGAP1
JUP
KIAA1328
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT19
KRT23
KRT5
LAMA3
LAMA4
LPHN1
MACF1
MAPRE1
MAPRE2
MBD5
MCM3AP
MUC1
MYH10
MYH11
MYO6
NAV1
NAV2
NAV3
NCKAP5
NCKAP5L
ND4
NEB
NOSTRIN
NUP153
NUP214
NUP54
NUP98
NUPL1
NUPL2
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PRKACA
PSMD1
PTPN13
RANBP9
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
SYNE1
TAF1
TFAP2A
TPR
TRIM21
TUBA4A
XPO1
YWHAQ
ZNF106
231 interactors:
AARS2
ABL1
ACSL4
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ATP5A1
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1L1
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HIST1H2BG
HIST2H4A
HNRNPA1
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
KCNK15
KCNK3
KCNK9
KIAA1429
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPC4
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSFA2
SSX2IP
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
Entrez ID
324
10971
HPRD ID
01439
00886
Ensembl ID
ENSG00000134982
ENSG00000134308
Uniprot IDs
B7Z2B6
P25054
Q4LE70
B4DMT8
P27348
PDB IDs
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
2BTP
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Mitotic Cell Cycle
Organelle Organization
Mitotic Cell Cycle Process
Protein Localization
Cell Cycle Process
Cellular Localization
Mitotic Nuclear Envelope Disassembly
Cellular Protein Localization
Establishment Of Localization In Cell
MRNA Transport
Nuclear Envelope Disassembly
Nucleus Organization
Nuclear Envelope Organization
Endomembrane System Organization
RNA Transport
Membrane Organization
Viral Process
RNA Localization
Cellular Component Assembly
Nucleocytoplasmic Transport
Nuclear Transport
Response To Stimulus
Signaling
Intracellular Transport
Cell Communication
Signal Transduction
Regulation Of Cellular Component Organization
Establishment Of Protein Localization
Cytoplasmic Transport
Anatomical Structure Development
Cytoskeleton Organization
Regulation Of Cell Cycle
Viral Transcription
Cell Differentiation
Regulation Of Glucose Transport
Protein Transport
Developmental Process
Viral Life Cycle
Regulation Of Protein Catabolic Process
Glucose Transport
Cell Development
Positive Regulation Of Wnt Signaling Pathway
Hexose Transport
Cellular Response To Stimulus
Protein Localization To Organelle
Negative Regulation Of Cell Cycle
Regulation Of Signal Transduction
Regulation Of Cellular Process
Cell Junction Assembly
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Organelle Organization
Cellular Process
Cellular Response To Organic Substance
Regulation Of Cellular Component Organization
Response To Organic Substance
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Developmental Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Metabolic Process
Response To Stress
Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle Process
Death
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Protein Localization
Intracellular Signal Transduction
Apoptotic Process
Cell Cycle Process
Anatomical Structure Development
Cell Death
Regulation Of Cellular Localization
System Development
Multicellular Organismal Development
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Abiotic Stimulus
Positive Regulation Of Protein Metabolic Process
Intracellular Transport
Regulation Of Signaling
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Regulation Of Phosphorylation
Innate Immune Response
MRNA Metabolic Process
Cellular Localization
Immune System Process
Regulation Of Kinase Activity
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?