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APC and NUP54
Number of citations of the paper that reports this interaction (PMID
20936779
)
48
Data Source:
BioGRID
(two hybrid)
APC
NUP54
Gene Name
adenomatous polyposis coli
nucleoporin 54kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Microtubule
Plasma Membrane
Cell-cell Adherens Junction
Tight Junction
Lateral Plasma Membrane
Lamellipodium
Beta-catenin Destruction Complex
Ruffle Membrane
Microtubule Plus-end
Axonal Growth Cone
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Nuclear Membrane
Molecular Function
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Nucleocytoplasmic Transporter Activity
Biological Process
Mitotic Cytokinesis
Kidney Development
Hair Follicle Development
Protein Complex Assembly
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Cell Cycle Arrest
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint
Cell Adhesion
Axonogenesis
Negative Regulation Of Cell Proliferation
Axis Specification
Anterior/posterior Pattern Specification
Dorsal/ventral Pattern Formation
Proximal/distal Pattern Formation
Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
T Cell Differentiation In Thymus
Somatic Stem Cell Maintenance
Negative Regulation Of Odontogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Regulation Of Osteoblast Differentiation
Regulation Of Osteoclast Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Cell Adhesion
Muscle Cell Cellular Homeostasis
Thymus Development
Regulation Of Nitrogen Compound Metabolic Process
Chromosome Organization
Positive Regulation Of Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Retina Development In Camera-type Eye
Canonical Wnt Signaling Pathway
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Tight Junction Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Mitotic Cell Cycle
Carbohydrate Metabolic Process
Protein Targeting
Nucleocytoplasmic Transport
Mitotic Nuclear Envelope Disassembly
Hexose Transport
Pathogenesis
Gene Expression
Regulation Of Glucose Transport
Glucose Transport
Viral Process
Viral Life Cycle
Viral Transcription
Cytokine-mediated Signaling Pathway
Small Molecule Metabolic Process
MRNA Transport
Transmembrane Transport
Pathways
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
Programmed Cell Death
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
Apoptotic cleavage of cellular proteins
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Apoptotic execution phase
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Prophase
HIV Infection
Nuclear import of Rev protein
Regulatory RNA pathways
Rev-mediated nuclear export of HIV RNA
Nuclear Envelope Breakdown
SLC-mediated transmembrane transport
M Phase
Influenza Life Cycle
HIV Life Cycle
Influenza Viral RNA Transcription and Replication
Rev-mediated nuclear export of HIV RNA
Myoclonic epilepsy of Lafora
Glycogen storage diseases
Transcriptional regulation by small RNAs
Vpr-mediated nuclear import of PICs
ISG15 antiviral mechanism
Interferon Signaling
Host Interactions of HIV factors
Nuclear Pore Complex (NPC) Disassembly
Regulation of Glucokinase by Glucokinase Regulatory Protein
Cytokine Signaling in Immune system
Interactions of Vpr with host cellular proteins
Interactions of Rev with host cellular proteins
Influenza Infection
Hexose transport
Cell Cycle, Mitotic
Late Phase of HIV Life Cycle
Antiviral mechanism by IFN-stimulated genes
Viral Messenger RNA Synthesis
Metabolism of carbohydrates
Glucose transport
Drugs
Diseases
GWAS
Protein-Protein Interactions
109 interactors:
ACTN1
AGFG1
ANKRD17
ANXA7
AP2B1
ARHGEF4
AXIN1
AXIN2
BUB1
BUB1B
C4A
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CSNK2A1
CTBP1
CTNNA1
CTNNB1
CYTH2
DLG3
DLGAP1
DST
EPAS1
ERBB2IP
EXPH5
FAM214A
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HSPA5
HTRA2
ING5
IQGAP1
JUP
KIAA1328
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT19
KRT23
KRT5
LAMA3
LAMA4
LPHN1
MACF1
MAPRE1
MAPRE2
MBD5
MCM3AP
MUC1
MYH10
MYH11
MYO6
NAV1
NAV2
NAV3
NCKAP5
NCKAP5L
ND4
NEB
NOSTRIN
NUP153
NUP214
NUP54
NUP98
NUPL1
NUPL2
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PRKACA
PSMD1
PTPN13
RANBP9
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
SYNE1
TAF1
TFAP2A
TPR
TRIM21
TUBA4A
XPO1
YWHAQ
ZNF106
14 interactors:
AP2B1
APC
CCDC85B
DGCR6
HAUS1
HGS
IFT20
KPNA1
KPNB1
KRT15
NUP62
NUPL1
NUTF2
SSR1
Entrez ID
324
53371
HPRD ID
01439
06352
Ensembl ID
ENSG00000134982
ENSG00000138750
Uniprot IDs
B7Z2B6
P25054
Q4LE70
B4DT35
Q7Z3B4
PDB IDs
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Mitotic Cell Cycle
Organelle Organization
Mitotic Cell Cycle Process
Protein Localization
Cell Cycle Process
Cellular Localization
Mitotic Nuclear Envelope Disassembly
Cellular Protein Localization
Establishment Of Localization In Cell
MRNA Transport
Nuclear Envelope Disassembly
Nucleus Organization
Nuclear Envelope Organization
Endomembrane System Organization
RNA Transport
Membrane Organization
Viral Process
RNA Localization
Cellular Component Assembly
Nucleocytoplasmic Transport
Nuclear Transport
Response To Stimulus
Signaling
Intracellular Transport
Cell Communication
Signal Transduction
Regulation Of Cellular Component Organization
Establishment Of Protein Localization
Cytoplasmic Transport
Anatomical Structure Development
Cytoskeleton Organization
Regulation Of Cell Cycle
Viral Transcription
Cell Differentiation
Regulation Of Glucose Transport
Protein Transport
Developmental Process
Viral Life Cycle
Regulation Of Protein Catabolic Process
Glucose Transport
Cell Development
Positive Regulation Of Wnt Signaling Pathway
Hexose Transport
Cellular Response To Stimulus
Protein Localization To Organelle
Negative Regulation Of Cell Cycle
Regulation Of Signal Transduction
Regulation Of Cellular Process
Cell Junction Assembly
Protein Transport
Establishment Of Protein Localization
Intracellular Transport
Cytoplasmic Transport
Protein Localization
Nucleocytoplasmic Transport
Nuclear Transport
Establishment Of Localization In Cell
Cellular Localization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Viral Life Cycle
Cellular Protein Localization
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Intracellular Protein Transport
Protein Localization To Organelle
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Viral Process
Execution Phase Of Apoptosis
Regulation Of ERBB Signaling Pathway
Establishment Of Protein Localization To Organelle
Apoptotic DNA Fragmentation
NLS-bearing Protein Import Into Nucleus
Protein Targeting
Cytokine-mediated Signaling Pathway
Intracellular Transport Of Virus
Cell Surface Receptor Signaling Pathway
Apoptotic Nuclear Changes
Mitotic Nuclear Envelope Disassembly
Nuclear Envelope Disassembly
Cellular Response To Cytokine Stimulus
Cellular Response To Organic Substance
Mitotic Cell Cycle Process
Transport
Response To Cytokine
Opsin Transport
Nuclear Envelope Organization
Mitotic Cell Cycle
Signal Transduction
Glucose Transport
Hexose Transport
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Membrane Organization
Viral Transcription
DNA Catabolic Process, Endonucleolytic
Signaling
Regulation Of Glucose Transport
Negative Regulation Of Intracellular Signal Transduction
Cell Communication
Response To Organic Substance
Tagcloud
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Difference)
?
12q
12q21
14q31
15q25
16q23
18p
19q13
20p12
20pq
20q12
21q21
3p14
4pq
5p14
5q14
6p12
7p12
8q23
cardia
cdkn2
fist
gej
mlvi2
mts1
nrasl3
parentheses
ptpn1
rca1
xpq
xq25
Tagcloud (Intersection)
?