APC and KIFAP3

Number of citations of the paper that reports this interaction (PMID 11912492)
47

Data Source:
HPRD (in vitro)

		APC	KIFAP3
Gene Name		adenomatous polyposis coli	kinesin-associated protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell-cell Adherens Junction Tight Junction Lateral Plasma Membrane Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Microtubule Plus-end Axonal Growth Cone	Condensed Nuclear Chromosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Axoneme Microtubule Cytoskeleton Kinesin II Complex Intraciliary Transport Particle Photoreceptor Connecting Cilium Ciliary Basal Body Extracellular Vesicular Exosome Primary Cilium Ciliary Tip Periciliary Membrane Compartment
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding	Protein Binding Kinesin Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Hair Follicle Development Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Adhesion Axonogenesis Negative Regulation Of Cell Proliferation Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Negative Regulation Of Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Muscle Cell Cellular Homeostasis Thymus Development Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Complex Assembly Organelle Organization Microtubule-based Process Microtubule-based Movement Signal Transduction Blood Coagulation Protein Localization Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Programmed Cell Death Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Apoptotic cleavage of cellular proteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Apoptotic execution phase phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer	Organelle biogenesis and maintenance MHC class II antigen presentation Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621)
Protein-Protein Interactions		109 interactors: ACTN1 AGFG1 ANKRD17 ANXA7 AP2B1 ARHGEF4 AXIN1 AXIN2 BUB1 BUB1B C4A CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CSNK2A1 CTBP1 CTNNA1 CTNNB1 CYTH2 DLG3 DLGAP1 DST EPAS1 ERBB2IP EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HSPA5 HTRA2 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 LPHN1 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MUC1 MYH10 MYH11 MYO6 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L ND4 NEB NOSTRIN NUP153 NUP214 NUP54 NUP98 NUPL1 NUPL2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 SYNE1 TAF1 TFAP2A TPR TRIM21 TUBA4A XPO1 YWHAQ ZNF106	18 interactors: APC AR DISC1 KIF3B MAP3K10 MAP3K11 MEST MINK1 NAA10 NCF2 NIPSNAP3A NUDT21 PEX19 RAP1GDS1 RBFOX1 RPGR SMC3 SRC
Entrez ID		324	22920
HPRD ID		01439	03499
Ensembl ID		ENSG00000134982	ENSG00000075945
Uniprot IDs		B7Z2B6 P25054 Q4LE70	Q92845
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Cell Cycle Process Protein Localization Cell Cycle Process Cellular Localization Mitotic Nuclear Envelope Disassembly Cellular Protein Localization Establishment Of Localization In Cell MRNA Transport Nuclear Envelope Disassembly Nucleus Organization Nuclear Envelope Organization Endomembrane System Organization RNA Transport Membrane Organization Viral Process RNA Localization Cellular Component Assembly Nucleocytoplasmic Transport Nuclear Transport Response To Stimulus Signaling Intracellular Transport Cell Communication Signal Transduction Regulation Of Cellular Component Organization Establishment Of Protein Localization Cytoplasmic Transport Anatomical Structure Development Cytoskeleton Organization Regulation Of Cell Cycle Viral Transcription Cell Differentiation Regulation Of Glucose Transport Protein Transport Developmental Process Viral Life Cycle Regulation Of Protein Catabolic Process Glucose Transport Cell Development Positive Regulation Of Wnt Signaling Pathway Hexose Transport Cellular Response To Stimulus Protein Localization To Organelle Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cellular Process Cell Junction Assembly	Organelle Organization Cytoskeleton Organization Microtubule-based Process Activation Of JNKK Activity Protein Autophosphorylation JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of MAPK Cascade Mitochondrial Calcium Ion Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Cellular Component Assembly Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Positive Regulation Of MAPK Cascade Microtubule Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of MAP Kinase Activity Mitotic Spindle Organization Regulation Of Cell Death MAPK Cascade Response To Progesterone Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Lipid Binding Positive Regulation Of Neuron Apoptotic Process Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of Metabolic Process T Cell Differentiation In Thymus Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a
Tagcloud (Intersection) ?