APC and MACF1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		APC	MACF1
Description		APC regulator of Wnt signaling pathway	microtubule actin crosslinking factor 1
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Beta-catenin Destruction Complex Leading Edge Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Plasma Membrane Bounded Cell Projection Wnt Signalosome	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Cell Leading Edge Ruffle Membrane Cell Projection
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Cadherin Binding Metal Ion Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Mitotic Cytokinesis Cell Fate Specification Heart Valve Development Endocardial Cushion Morphogenesis DNA Damage Response Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule-based Movement Protein-containing Complex Assembly Bicellular Tight Junction Assembly Regulation Of Primary Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Projection Organization Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Process Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Membrane Regulation Of Neuron Projection Arborization
Pathways		Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Drugs
Diseases		Cancer of the anal canal Familial adenomatous polyposis Gastric cancer Esophageal cancer Gallbladder cancer
GWAS		Age at first sexual intercourse ( 34211149) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Appendicular lean mass ( 33097823) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Daytime nap ( 33568662) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)	Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 20686565 25961943) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 27189021 28869590 29358691 32499647 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)
Interacting Genes		135 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 ATOSA AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG1 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PKNOX1 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 ZNF106 ZNF510	38 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DSCAM DSCR9 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN LCOR MAPK9 MAPRE1 MTNR1B NRCAM NRIP1 NRXN1 NRXN2 PCNT PKNOX1 PLXND1 PRKCD RIPK4 SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC USP7
Entrez ID		324	23499
HPRD ID		01439	09750
Ensembl ID		ENSG00000134982	ENSG00000127603
Uniprot IDs		P25054 R4GMU6	H3BPE1 O94854 Q6ZSD7 Q9UPN3
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H 7F6M 7F7O 7XTY 8GSJ 8X2Q	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?		Organelle Organization Structural Constituent Of Nuclear Pore Cytoskeleton Organization Supramolecular Fiber Organization Cytosol MRNA Transport Nuclear Export Nuclear Pore Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Beta-catenin Destruction Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Nuclear Membrane RNA Export From Nucleus Cellular Localization Cytoskeleton Intracellular Protein Localization Regulation Of Nucleocytoplasmic Transport Intracellular Transport Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Nuclear Envelope Establishment Of Localization In Cell Cadherin Binding Regulation Of Protein Localization Actin Filament Binding Glutamatergic Synapse Regulation Of Cellular Localization Protein Export From Nucleus Hemidesmosome Intracellular Protein Transport Actin Binding Nucleus Protein Transport Cellular Component Assembly Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Cytoplasm Regulation Of Cytoskeleton Organization Canonical Wnt Signaling Pathway Regulation Of Intracellular Transport Structural Molecule Activity Intermediate Filament Organization Nuclear Pore Nuclear Basket Regulation Of Intracellular Protein Transport Nuclear Pore Organization Microtubule Regulation Of Centromeric Sister Chromatid Cohesion	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Vocal Learning Positive Regulation Of Axonogenesis Observational Learning Positive Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Synapse Assembly Neuron Recognition Auditory Behavior Mechanosensory Behavior Social Behavior Vocalization Behavior Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Regulation Of Axonogenesis Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of Nervous System Development Regulation Of Axon Extension Glutamatergic Synapse Negative Regulation Of Filopodium Assembly Cell Projection Morphogenesis Anatomical Structure Morphogenesis Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Family Protein Binding Angiogenesis Postsynaptic Density Protein 95 Clustering Neuron Projection Development Positive Regulation Of Axon Extension Modulation Of Chemical Synaptic Transmission Neurotransmitter Secretion Postsynaptic Membrane Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Neurogenesis Regulation Of Filopodium Assembly Regulation Of Cell Projection Assembly Synapse Cell Recognition Postsynaptic Membrane Organization Axon Synapse Organization Presynaptic Membrane Positive Regulation Of Intracellular Transport Neuronal Ion Channel Clustering Regulation Of Postsynapse Organization Cilium Assembly
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