APC and AP2B1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		APC	AP2B1
Gene Name		adenomatous polyposis coli	adaptor-related protein complex 2, beta 1 subunit
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell-cell Adherens Junction Tight Junction Lateral Plasma Membrane Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Microtubule Plus-end Axonal Growth Cone	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Mitotic Cytokinesis Kidney Development Hair Follicle Development Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Cell Adhesion Axonogenesis Negative Regulation Of Cell Proliferation Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process T Cell Differentiation In Thymus Somatic Stem Cell Maintenance Negative Regulation Of Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Muscle Cell Cellular Homeostasis Thymus Development Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Retina Development In Camera-type Eye Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Programmed Cell Death Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex Apoptotic cleavage of cellular proteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Apoptotic execution phase phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		109 interactors: ACTN1 AGFG1 ANKRD17 ANXA7 AP2B1 ARHGEF4 AXIN1 AXIN2 BUB1 BUB1B C4A CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CSNK2A1 CTBP1 CTNNA1 CTNNB1 CYTH2 DLG3 DLGAP1 DST EPAS1 ERBB2IP EXPH5 FAM214A FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HSPA5 HTRA2 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 LPHN1 MACF1 MAPRE1 MAPRE2 MBD5 MCM3AP MUC1 MYH10 MYH11 MYO6 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L ND4 NEB NOSTRIN NUP153 NUP214 NUP54 NUP98 NUPL1 NUPL2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PRKACA PSMD1 PTPN13 RANBP9 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 SYNE1 TAF1 TFAP2A TPR TRIM21 TUBA4A XPO1 YWHAQ ZNF106	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		324	163
HPRD ID		01439	03015
Ensembl ID		ENSG00000134982	ENSG00000006125
Uniprot IDs		B7Z2B6 P25054 Q4LE70	K7EJT8 P63010 Q96EL6
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Cell Cycle Process Protein Localization Cell Cycle Process Cellular Localization Mitotic Nuclear Envelope Disassembly Cellular Protein Localization Establishment Of Localization In Cell MRNA Transport Nuclear Envelope Disassembly Nucleus Organization Nuclear Envelope Organization Endomembrane System Organization RNA Transport Membrane Organization Viral Process RNA Localization Cellular Component Assembly Nucleocytoplasmic Transport Nuclear Transport Response To Stimulus Signaling Intracellular Transport Cell Communication Signal Transduction Regulation Of Cellular Component Organization Establishment Of Protein Localization Cytoplasmic Transport Anatomical Structure Development Cytoskeleton Organization Regulation Of Cell Cycle Viral Transcription Cell Differentiation Regulation Of Glucose Transport Protein Transport Developmental Process Viral Life Cycle Regulation Of Protein Catabolic Process Glucose Transport Cell Development Positive Regulation Of Wnt Signaling Pathway Hexose Transport Cellular Response To Stimulus Protein Localization To Organelle Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cellular Process Cell Junction Assembly	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?