APC and PTPN13

Number of citations: 0 (PubMedID 10951583)
Data Source: HPRD (two hybrid, in vitro)

		APC	PTPN13
Name		APC regulator of Wnt signaling pathway	protein tyrosine phosphatase non-receptor type 13
Structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Beta-catenin Destruction Complex Leading Edge Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Plasma Membrane Bounded Cell Projection Wnt Signalosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Mitotic Cytokinesis Cell Fate Specification Heart Valve Development Endocardial Cushion Morphogenesis DNA Damage Response Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule-based Movement Protein-containing Complex Assembly Bicellular Tight Junction Assembly Regulation Of Primary Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly
Pathways		Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Diseases		Cancer of the anal canal Familial adenomatous polyposis Gastric cancer Esophageal cancer Gallbladder cancer	None
GWAS		Age at first sexual intercourse ( 34211149 ) Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Appendicular lean mass ( 33097823 ) Body mass index ( 29273807 ) Colorectal cancer or advanced adenoma ( 30510241 ) Daytime nap ( 33568662 ) Heel bone mineral density ( 30598549 ) Reaction time ( 29844566 ) Total body bone mineral density ( 29304378 )	Appendicular lean mass ( 33097823 ) Eyebrow thickness ( 26926045 ) Hemoglobin levels ( 32327693 ) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854 ) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854 ) Tinnitus ( 33742053 ) Word spelling ( 30741946 )
Interacting Genes		135 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 ATOSA AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG1 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PKNOX1 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 ZNF106 ZNF510	26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ
Entrez ID		324	5783
HPRD ID		01439	02602
Ensembl ID		ENSG00000134982	ENSG00000163629
Uniprot IDs		P25054 R4GMU6	Q12923
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H 7F6M 7F7O 7XTY 8GSJ 8X2Q	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
GO Terms Enriched among Interactors		Organelle Organization Structural Constituent Of Nuclear Pore Cytoskeleton Organization Supramolecular Fiber Organization Cytosol MRNA Transport Nuclear Export Nuclear Pore Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Beta-catenin Destruction Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Nuclear Membrane RNA Export From Nucleus Cellular Localization Cytoskeleton Intracellular Protein Localization Regulation Of Nucleocytoplasmic Transport Intracellular Transport Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Nuclear Envelope Establishment Of Localization In Cell Cadherin Binding Regulation Of Protein Localization Actin Filament Binding Glutamatergic Synapse Regulation Of Cellular Localization Protein Export From Nucleus Hemidesmosome Intracellular Protein Transport Actin Binding Nucleus Protein Transport Cellular Component Assembly Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Cytoplasm Regulation Of Cytoskeleton Organization Canonical Wnt Signaling Pathway Regulation Of Intracellular Transport Structural Molecule Activity Intermediate Filament Organization Nuclear Pore Nuclear Basket Regulation Of Intracellular Protein Transport Nuclear Pore Organization Microtubule Regulation Of Centromeric Sister Chromatid Cohesion	Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium