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APC and KRT15
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
36
Data Source:
BioGRID
(two hybrid)
APC
KRT15
Description
APC regulator of Wnt signaling pathway
keratin 15
Image
No pdb structure
GO Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Beta-catenin Destruction Complex
Leading Edge Membrane
Ruffle Membrane
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Plasma Membrane Bounded Cell Projection
Wnt Signalosome
Nucleus
Cytosol
Cytoskeleton
Intermediate Filament
Keratin Filament
Extracellular Exosome
Molecular Function
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Structural Constituent Of Skin Epidermis
Scaffold Protein Binding
Biological Process
Mitotic Cytokinesis
Cell Fate Specification
Heart Valve Development
Endocardial Cushion Morphogenesis
DNA Damage Response
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Assembly Checkpoint Signaling
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Wnt Signaling Pathway
Cell Migration
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Regulation Of Microtubule-based Movement
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Centrosome
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Morphogenesis Of An Epithelium
Epidermis Development
Epithelial Cell Differentiation
Intermediate Filament Organization
Pathways
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Keratinization
Formation of the cornified envelope
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
Cancer of the anal canal
Familial adenomatous polyposis
Gastric cancer
Esophageal cancer
Gallbladder cancer
GWAS
Age at first sexual intercourse (
34211149
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Appendicular lean mass (
33097823
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Daytime nap (
33568662
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
135 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
ATOSA
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG1
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PKNOX1
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
ZNF106
ZNF510
144 interacting genes:
ABI2
ABI3
ABLIM1
AMOT
AMOTL2
ANKRD36BP1
APC
ARC
ARFIP2
ATP5PO
BEX2
C1orf216
CALCOCO1
CARD9
CATSPERT
CCDC120
CCDC185
CCDC187
CCDC87
CCHCR1
CCNB1IP1
CCNC
CDK18
CEP57
COX5B
CREB5
CYTH4
DEPP1
DES
DEUP1
DGCR6L
DRC4
DTNB
EFHC1
ENKD1
EPC1
EXOC8
FAM107A
FAM110A
GFAP
GLYCTK
HAPLN2
HAUS1
HGS
HMG20B
HOXB6
IKBIP
KANSL1
KDM1A
KIAA0408
KIAA1217
KIFC3
KLC3
KLC4
KRT1
KRT18
KRT19
KRT20
KRT3
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT73
KRT74
KRT76
KRT77
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
LDOC1
LMO2
LMO4
LNX1
MAD2L1BP
MBD3
MCM10
MORN3
MOS
NEFL
NIF3L1
NOC4L
NUDT18
NUP54
OIP5
PCM1
PIK3R2
PKN1
PPP1R18
PRPF31
PRPH
PSMA1
PSMB1
PSMC5
RAD51D
RAMAC
RCOR3
RHPN1
RIBC1
RIBC2
RNF6
RPP25
RSPH14
SGF29
SIRPA
SMARCB1
SMARCD1
SMARCE1
SNAPIN
SPG21
SSX2IP
TBC1D21
TCHP
TEKT4
TELO2
TIMM8A
TLE5
TMSB4X
TRIM42
TRIML2
TSG101
TTC23
TUBGCP4
TXLNA
TXLNB
TXNDC11
USHBP1
USP2
WAC
ZC2HC1C
ZFYVE26
ZGPAT
ZNF417
ZNF576
ZNF638
ZNF688
Entrez ID
324
3866
HPRD ID
01439
01009
Ensembl ID
ENSG00000134982
ENSG00000171346
Uniprot IDs
P25054
R4GMU6
B3KVF5
P19012
PDB IDs
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
7F6M
7F7O
7XTY
8GSJ
8X2Q
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Structural Constituent Of Nuclear Pore
Cytoskeleton Organization
Supramolecular Fiber Organization
Cytosol
MRNA Transport
Nuclear Export
Nuclear Pore
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Beta-catenin Destruction Complex
Nuclear Transport
Nucleocytoplasmic Transport
RNA Transport
Nuclear Membrane
RNA Export From Nucleus
Cellular Localization
Cytoskeleton
Intracellular Protein Localization
Regulation Of Nucleocytoplasmic Transport
Intracellular Transport
Nucleobase-containing Compound Transport
Nuclear Localization Sequence Binding
Nuclear Envelope
Establishment Of Localization In Cell
Cadherin Binding
Regulation Of Protein Localization
Actin Filament Binding
Glutamatergic Synapse
Regulation Of Cellular Localization
Protein Export From Nucleus
Hemidesmosome
Intracellular Protein Transport
Actin Binding
Nucleus
Protein Transport
Cellular Component Assembly
Positive Regulation Of Nucleocytoplasmic Transport
Establishment Of Protein Localization
Cytoplasm
Regulation Of Cytoskeleton Organization
Canonical Wnt Signaling Pathway
Regulation Of Intracellular Transport
Structural Molecule Activity
Intermediate Filament Organization
Nuclear Pore Nuclear Basket
Regulation Of Intracellular Protein Transport
Nuclear Pore Organization
Microtubule
Regulation Of Centromeric Sister Chromatid Cohesion
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Structural Constituent Of Skin Epidermis
Keratin Filament
Intermediate Filament
Keratinization
Cytoskeleton Organization
Supramolecular Fiber Organization
Organelle Organization
Protein Binding
Cytoskeleton
Structural Constituent Of Cytoskeleton
Microtubule-based Process
Intermediate Filament Cytoskeleton
Microtubule-based Movement
Centrosome
Axonemal A Tubule Inner Sheath
Flagellated Sperm Motility
Sperm Motility
Intermediate Filament Polymerization Or Depolymerization
Cilium-dependent Cell Motility
Cilium Movement Involved In Cell Motility
Brahma Complex
NpBAF Complex
Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
RSC-type Complex
Regulation Of Sister Chromatid Segregation
NBAF Complex
Cell Projection
Microtubule Cytoskeleton Organization
Motile Cilium
Nucleosome Disassembly
Microtubule
Cilium Movement
Sperm Mitochondrial Sheath Assembly
Protein-DNA Complex Disassembly
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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