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KCNIP3 and PSEN2
Number of citations of the paper that reports this interaction (PMID
9771752
)
57
Data Source:
HPRD
(two hybrid, in vivo)
KCNIP3
PSEN2
Gene Name
Kv channel interacting protein 3, calsenilin
presenilin 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Dendrite
Protein-DNA Complex
Axon Terminus
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Axon
Growth Cone
Neuromuscular Junction
Ciliary Rootlet
Ciliary Basal Body
Neuronal Cell Body
Dendritic Shaft
Protein Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Transcription Corepressor Activity
Voltage-gated Ion Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein C-terminus Binding
Potassium Channel Regulator Activity
Sequence-specific DNA Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Sensory Perception Of Pain
Regulation Of Ion Transmembrane Transport
Regulation Of Neuron Apoptotic Process
Behavioral Response To Pain
Potassium Ion Transmembrane Transport
Response To Hypoxia
Cell Fate Specification
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Hair Follicle Development
Hematopoietic Progenitor Cell Differentiation
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Signaling Pathway
Notch Receptor Processing
Axon Guidance
Memory
Protein Transport
Protein Processing
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Forebrain Development
Membrane Protein Intracellular Domain Proteolysis
Negative Regulation Of Protein Complex Assembly
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Lung Alveolus Development
Thymus Development
Brain Morphogenesis
Beta-amyloid Metabolic Process
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Cardiac Muscle Contraction
Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Axon guidance
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH2
EPH-ephrin mediated repulsion of cells
Signaling by NOTCH1
EPH-Ephrin signaling
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Signaling by NOTCH4
Regulated proteolysis of p75NTR
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
Signaling by NOTCH
p75 NTR receptor-mediated signalling
Signaling by ERBB4
NOTCH2 Activation and Transmission of Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Nuclear signaling by ERBB4
NRIF signals cell death from the nucleus
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH3
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADRBK1
CALM2
CASP3
CD177
CLN3
CREB1
CREM
GRK6
IGF1R
IGLV3-25
IL6ST
MAVS
PCBD2
PPP3CA
PSEN1
PSEN2
TARBP2
58 interactors:
AAMP
ACTG1
APH1A
APH1B
APP
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
MGEA5
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
30818
5664
HPRD ID
05232
02860
Ensembl ID
ENSG00000115041
ENSG00000143801
Uniprot IDs
Q9Y2W7
P49810
PDB IDs
2E6W
Enriched GO Terms of Interacting Partners
?
Amyloid Precursor Protein Catabolic Process
Regulation Of Immune System Process
Negative Regulation Of Protein Phosphorylation
Cellular Response To Organic Substance
Response To Organic Substance
Positive Regulation Of Metabolic Process
Negative Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Regulation Of Protein Phosphorylation
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Immune Response
Regulation Of Phosphorylation
Regulation Of Immune Response
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Phosphorus Metabolic Process
Signaling
Negative Regulation Of Cellular Metabolic Process
Cell Communication
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Signaling
Regulation Of Protein Kinase Activity
Activation Of Phospholipase C Activity
Negative Regulation Of Signaling
Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Phospholipase C Activity
Regulation Of Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Protein Kinase Activity
Response To Stress
Negative Regulation Of Kinase Activity
Protein Processing
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Programmed Cell Death
Learning Or Memory
Notch Receptor Processing
Cell Death
Death
Apoptotic Process
Programmed Cell Death
Notch Signaling Pathway
Regulation Of Apoptotic Process
Cell Differentiation
Regulation Of Cell Death
Cell Development
Positive Regulation Of Apoptotic Process
Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Anatomical Structure Morphogenesis
Developmental Process
Signal Transduction
Protein Processing
Cellular Response To Stimulus
Signaling
Execution Phase Of Apoptosis
Response To Stimulus
Multicellular Organismal Development
System Development
Cell Communication
Anatomical Structure Development
Membrane Protein Intracellular Domain Proteolysis
Apoptotic Signaling Pathway
Cell Morphogenesis
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Neuron Differentiation
Regulation Of Cellular Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Positive Regulation Of Proteolysis
Intracellular Receptor Signaling Pathway
Response To External Stimulus
Cardiovascular System Development
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Positive Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Positive Regulation Of Peptidase Activity
Membrane Protein Proteolysis
Positive Regulation Of Catalytic Activity
Generation Of Neurons
Cell Cycle
Negative Regulation Of Cell Death
Tagcloud
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Difference)
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
casp3
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Intersection)
?