KCNIP3 and ZG16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNIP3	ZG16
Description		potassium voltage-gated channel interacting protein 3	zymogen granule protein 16
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Cytoplasmic Vesicle Zymogen Granule Membrane Mucus Layer
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Protein Binding Carbohydrate Binding Peptidoglycan Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Protein Transport Defense Response To Gram-positive Bacterium Suppression Of Symbiont Entry Into Host
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	11 interacting genes: ASPH CTNNA3 GLYCTK KCNIP3 PUF60 SGTA SGTB UBE2I UBQLN1 UBQLN2 UBQLN4
Entrez ID		30818	653808
HPRD ID		05232
Ensembl ID		ENSG00000115041	ENSG00000174992
Uniprot IDs		Q9Y2W7	O60844
PDB IDs		2E6W	3APA 3VY6 3VY7 3VZE 3VZF 3VZG 7O3I 7O4P 7O88
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Autophagosome Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Macromolecule Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Protein Catabolic Process Identical Protein Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport Catabolic Process SUMO Conjugating Enzyme Activity Negative Regulation Of Store-operated Calcium Channel Activity Glycerate Kinase Activity Regulation Of Monoatomic Ion Transmembrane Transport Autophagy Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Regulation Of Autophagy Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Striated Muscle Contraction RING-like Zinc Finger Domain Binding Autophagosome Organization
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