PSEN2 and UBQLN1

Number of citations of the paper that reports this interaction (PubMedID 11076969)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PSEN2	UBQLN1
Description		presenilin 2	ubiquilin 1
Image
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Macroautophagy Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy ERAD Pathway Negative Regulation Of Transport Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CARINH CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CEBPA CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 ENTREP1 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SUSD4 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM37 TMEM67 TMUB2 TNFAIP3 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 WWP2 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343
Entrez ID		5664	29979
HPRD ID		02860	05440
Ensembl ID		ENSG00000143801	ENSG00000135018
Uniprot IDs		P49810	Q9UMX0
PDB IDs		7Y5X 7Y5Z	2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation	Extracellular Region Extracellular Ligand-gated Monoatomic Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Protein Binding Extracellular Space GABA-gated Chloride Ion Channel Activity Regulation Of Postsynaptic Membrane Potential Gamma-aminobutyric Acid Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Endoplasmic Reticulum Lumen Chloride Channel Complex Chloride Channel Activity Inhibitory Synapse Assembly Postsynaptic Membrane Positive Regulation Of Glial Cell Differentiation Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tag Activity Regulation Of Membrane Potential Transmembrane Signaling Receptor Activity Cell-cell Signaling Endoplasmic Reticulum Behavioral Response To Nicotine Regulation Of Tumor Necrosis Factor Production Regulation Of Mononuclear Cell Migration Regulation Of Proteolysis Synaptic Signaling Signaling Chemical Synaptic Transmission Positive Regulation Of Oligodendrocyte Differentiation Chloride Transmembrane Transport Benzodiazepine Receptor Activity Ubiquitin Binding GABA-ergic Synapse Proteolysis Monoatomic Anion Transmembrane Transport Macromolecule Catabolic Process Cell Communication Regulation Of Oligodendrocyte Differentiation Regulation Of Leukocyte Migration Chloride Transport Trans-synaptic Signaling Monoatomic Ion Channel Activity Oligosaccharyltransferase Complex Positive Regulation Of Nervous System Development Monoatomic Anion Transport
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