KCNIP3 and GRK6

Number of citations of the paper that reports this interaction (PubMedID 17102134)
0

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		KCNIP3	GRK6
Description		potassium voltage-gated channel interacting protein 3	G protein-coupled receptor kinase 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Cytoplasm Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription	G alpha (s) signalling events
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R
Entrez ID		30818	2870
HPRD ID		05232	02925
Ensembl ID		ENSG00000115041	ENSG00000198055
Uniprot IDs		Q9Y2W7	B3KPS5 P43250
PDB IDs		2E6W	2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process	Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process
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