KCNIP3 and CD177

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		KCNIP3	CD177
Description		potassium voltage-gated channel interacting protein 3	CD177 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Extracellular Region Plasma Membrane Membrane Lamellipodium Secretory Granule Membrane Specific Granule Membrane Cell Projection Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Side Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Protease Binding Integrin Binding Protein Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Immune System Process Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Endocytosis Positive Regulation Of Superoxide Anion Generation Protein Localization To Cell Surface Positive Regulation Of Neutrophil Degranulation Innate Immune Response Cell-cell Junction Maintenance Neutrophil Extravasation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Neutrophil Migration Regulation Of Integrin-mediated Signaling Pathway
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription	Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Blood protein levels ( 30072576)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	3 interacting genes: EWSR1 KCNIP3 SHBG
Entrez ID		30818	57126
HPRD ID		05232	01222
Ensembl ID		ENSG00000115041	ENSG00000204936
Uniprot IDs		Q9Y2W7	A0A087WVM2 Q8N6Q3
PDB IDs		2E6W
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process
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