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PSEN2 and CASP3
Number of citations of the paper that reports this interaction (PubMedID
9990034
)
53
Data Source:
HPRD
(in vivo)
PSEN2
CASP3
Description
presenilin 2
caspase 3
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Synaptic Vesicle
Membrane
Nuclear Membrane
Protein-containing Complex
Presynaptic Membrane
Gamma-secretase Complex
Synaptic Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Postsynaptic Density
Death-inducing Signaling Complex
Neuronal Cell Body
Glutamatergic Synapse
Molecular Function
Protein Binding
Peptidase Activity
Hydrolase Activity
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Protease Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Death Receptor Binding
Protein Binding
Enzyme Activator Activity
Peptidase Activity
Cysteine-type Peptidase Activity
Phospholipase A2 Activator Activity
Hydrolase Activity
Protein-containing Complex Binding
Biological Process
Response To Hypoxia
Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Amyloid-beta Formation
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Calcium Ion Homeostasis
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Luteolysis
Response To Hypoxia
B Cell Homeostasis
Negative Regulation Of Cytokine Production
Proteolysis
Apoptotic Process
DNA Damage Response
Axonal Fasciculation
Heart Development
Sensory Perception Of Sound
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To Xenobiotic Stimulus
Response To UV
Response To Wounding
Response To Glucose
Response To Metal Ion
Response To X-ray
Regulation Of Macroautophagy
Protein Processing
Hippocampus Development
Protein Catabolic Process
Neuron Differentiation
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Response To Nicotine
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Response To Hydrogen Peroxide
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cell Cycle
Negative Regulation Of Activated T Cell Proliferation
Neurotrophin TRK Receptor Signaling Pathway
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Neuron Apoptotic Process
Protein Maturation
Anterior Neural Tube Closure
Protein Poly-ADP-ribosylation
Pyroptotic Inflammatory Response
Leukocyte Apoptotic Process
Response To Anesthetic
Cellular Response To Staurosporine
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Regulation Of Synaptic Vesicle Cycle
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Amyloid-beta Formation
Epithelial Cell Apoptotic Process
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Pyroptosis
CASP4-mediated substrate cleavage
CASP5-mediated substrate cleavage
Drugs
Pamidronic acid
Acetylsalicylic acid
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
Emricasan
Incadronic acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Tributyrin
Oleandrin
PAC-1
Glycyrrhizic acid
Diseases
Alzheimer's disease (AD)
GWAS
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Kawasaki disease (
33106546
33772158
)
Interacting Genes
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
157 interacting genes:
ACIN1
ADD1
AFP
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ARNT
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SNRNP70
SOCS5
SOHLH1
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
Entrez ID
5664
836
HPRD ID
02860
02799
Ensembl ID
ENSG00000143801
ENSG00000164305
Uniprot IDs
P49810
A8MVM1
P42574
PDB IDs
7Y5X
7Y5Z
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
4PRY
4PS0
4QTX
4QTY
4QU0
4QU5
4QU8
4QU9
4QUA
4QUB
4QUD
4QUE
4QUG
4QUH
4QUI
4QUJ
4QUL
5I9B
5I9T
5IAB
5IAE
5IAG
5IAJ
5IAK
5IAN
5IAR
5IAS
5IBC
5IBP
5IBR
5IC4
7XN4
7XN5
7XN6
Enriched GO Terms of Interacting Partners
?
Cytosol
Notch Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Gamma-secretase Complex
Cytoplasm
Protein Processing
Notch Receptor Processing
Amyloid-beta Formation
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Membrane Protein Intracellular Domain Proteolysis
Protein Maturation
Cellular Response To Staurosporine
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Luteolysis
Endopeptidase Activator Activity
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Organelle Assembly
Death-inducing Signaling Complex
Amyloid Precursor Protein Metabolic Process
Amyloid-beta Metabolic Process
Execution Phase Of Apoptosis
Golgi Membrane
Proteolysis
Positive Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Membrane Protein Proteolysis
Regulation Of Autophagy
Positive Regulation Of Proteolysis
Cellular Response To Alkaloid
Organelle Organization
Angiogenesis
Negative Regulation Of Programmed Cell Death
Ovulation Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Process
Cytosol
Intracellular Signal Transduction
Cytoplasm
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Programmed Cell Death
Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Apoptotic Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Apoptotic Signaling Pathway
Enzyme Binding
Cellular Response To Oxygen-containing Compound
Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Cellular Response To Stress
Regulation Of Protein Metabolic Process
Positive Regulation Of Signaling
Nucleus
Regulation Of Neuron Apoptotic Process
Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Immune System Process
Protein Modification Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Immune System Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune Response
Protein Phosphorylation
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Macromolecule Metabolic Process
Developmental Process
Positive Regulation Of Multicellular Organismal Process
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Tagcloud (Intersection)
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