PSEN2 and ACTG1

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PSEN2	ACTG1
Gene Name		presenilin 2	actin gamma 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Ciliary Rootlet Ciliary Basal Body Neuronal Cell Body Dendritic Shaft Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Cell Fate Specification Somitogenesis Negative Regulation Of Protein Phosphorylation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Myeloid Leukocyte Differentiation Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Axon Guidance Memory Protein Transport Protein Processing Dorsal/ventral Neural Tube Patterning Embryonic Limb Morphogenesis Forebrain Development Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lung Alveolus Development Thymus Development Brain Morphogenesis Beta-amyloid Metabolic Process Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Cardiac Muscle Contraction Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AAMP ACTG1 APH1A APH1B APP BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B MGEA5 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		5664	71
HPRD ID		02860	00017
Ensembl ID		ENSG00000143801	ENSG00000184009
Uniprot IDs		P49810	P63261
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Cell Death Death Apoptotic Process Programmed Cell Death Notch Signaling Pathway Regulation Of Apoptotic Process Cell Differentiation Regulation Of Cell Death Cell Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Developmental Process Signal Transduction Protein Processing Cellular Response To Stimulus Signaling Execution Phase Of Apoptosis Response To Stimulus Multicellular Organismal Development System Development Cell Communication Anatomical Structure Development Membrane Protein Intracellular Domain Proteolysis Apoptotic Signaling Pathway Cell Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Neuron Differentiation Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Response To External Stimulus Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Peptidase Activity Membrane Protein Proteolysis Positive Regulation Of Catalytic Activity Generation Of Neurons Cell Cycle Negative Regulation Of Cell Death	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?