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PSEN2
Description
presenilin 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Synaptic Vesicle
Membrane
Nuclear Membrane
Protein-containing Complex
Presynaptic Membrane
Gamma-secretase Complex
Synaptic Membrane
Molecular Function
Protein Binding
Peptidase Activity
Hydrolase Activity
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Biological Process
Response To Hypoxia
Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Amyloid-beta Formation
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Calcium Ion Homeostasis
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Drugs
Diseases
Alzheimer's disease (AD)
GWAS
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
5664
HPRD ID
02860
Ensembl ID
ENSG00000143801
Uniprot IDs
P49810
PDB IDs
7Y5X
7Y5Z
Enriched GO Terms of Interacting Partners
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Cytosol
Notch Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Gamma-secretase Complex
Cytoplasm
Protein Processing
Notch Receptor Processing
Amyloid-beta Formation
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Membrane Protein Intracellular Domain Proteolysis
Protein Maturation
Cellular Response To Staurosporine
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Luteolysis
Endopeptidase Activator Activity
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Organelle Assembly
Death-inducing Signaling Complex
Amyloid Precursor Protein Metabolic Process
Amyloid-beta Metabolic Process
Execution Phase Of Apoptosis
Golgi Membrane
Proteolysis
Positive Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Membrane Protein Proteolysis
Regulation Of Autophagy
Positive Regulation Of Proteolysis
Cellular Response To Alkaloid
Organelle Organization
Angiogenesis
Negative Regulation Of Programmed Cell Death
Ovulation Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Smooth Muscle Cell Differentiation
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