KCNIP3 and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		KCNIP3	PCBD2
Description		potassium voltage-gated channel interacting protein 3	pterin-4 alpha-carbinolamine dehydratase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Mitochondrion
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951 28552196) Type 2 diabetes ( 24509480)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	41 interacting genes: AATF APP ASCC2 BCAS2 BRF1 C1D CDC5L CENPK CERS3 CHAF1A FBXO7 GTF2E1 GUCD1 HES4 IRF2BP1 KCNIP3 KLC3 LGALS14 MAGEA11 MAGEA6 MED21 MED30 MED4 MED7 MET MRFAP1 PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SPG21 SSX3 SSX5 STAT3 TAL2 TGIF2LY USP2-AS1 XBP1 ZZZ3
Entrez ID		30818	84105
HPRD ID		05232	17824
Ensembl ID		ENSG00000115041	ENSG00000132570
Uniprot IDs		Q9Y2W7	Q9H0N5
PDB IDs		2E6W	4C45
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Preinitiation Complex Assembly Transcription Coactivator Activity Core Mediator Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Mediator Complex Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II Preinitiation Complex Assembly Nuclear Vitamin D Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Coregulator Activity Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Initiation U2-type Catalytic Step 2 Spliceosome Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-1 Beta Production Regulation Of DNA-templated Transcription Elongation Negative Regulation Of Metabolic Process Transcription Corepressor Activity Ubiquitin Ligase Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Interleukin-1 Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Stem Cell Population Maintenance
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