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PSEN2 and RAB11A
Number of citations of the paper that reports this interaction (PubMedID
10369872
)
0
Data Source:
HPRD
(two hybrid, in vivo)
PSEN2
RAB11A
Description
presenilin 2
RAB11A, member RAS oncogene family
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Synaptic Vesicle
Membrane
Nuclear Membrane
Protein-containing Complex
Presynaptic Membrane
Gamma-secretase Complex
Synaptic Membrane
Golgi Membrane
Spindle Pole
Cytoplasm
Endosome
Multivesicular Body
Golgi Apparatus
Trans-Golgi Network
Centrosome
Centriole
Kinetochore Microtubule
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Transport Vesicle
Cytoplasmic Vesicle Membrane
Endocytic Vesicle Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Vesicle
Cleavage Furrow
Trans-Golgi Network Membrane
Protein-containing Complex
Phagocytic Vesicle
Recycling Endosome
Recycling Endosome Membrane
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Presynaptic Endosome
Postsynaptic Recycling Endosome
Glutamatergic Synapse
Molecular Function
Protein Binding
Peptidase Activity
Hydrolase Activity
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Microtubule Binding
Hydrolase Activity
Syntaxin Binding
Myosin V Binding
Dynein Light Intermediate Chain Binding
Biological Process
Response To Hypoxia
Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Amyloid-beta Formation
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Calcium Ion Homeostasis
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Mitotic Cytokinesis
Exocytosis
Vesicle Docking Involved In Exocytosis
Microtubule-based Movement
Mitotic Metaphase Chromosome Alignment
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Transport
Vesicle-mediated Transport
Astral Microtubule Organization
Neuron Projection Development
Melanosome Transport
Regulation Of Cytokinesis
Protein Localization To Cell Surface
Multivesicular Body Assembly
Golgi To Plasma Membrane Protein Transport
Positive Regulation Of Cilium Assembly
Regulation Of Long-term Neuronal Synaptic Plasticity
Plasma Membrane To Endosome Transport
Regulation Of Protein Transport
Establishment Of Vesicle Localization
Regulation Of Vesicle-mediated Transport
Early Endosome To Recycling Endosome Transport
Protein Localization To Cilium
Protein Transmembrane Transport
Establishment Of Protein Localization To Organelle
Protein Localization To Plasma Membrane
Establishment Of Protein Localization To Membrane
Mitotic Spindle Assembly
Vesicle-mediated Transport To The Plasma Membrane
Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Vesicle-mediated Transport In Synapse
Synaptic Vesicle Endosomal Processing
Amyloid-beta Clearance By Transcytosis
Regulation Of Cilium Assembly
Regulation Of Early Endosome To Recycling Endosome Transport
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Mitotic Cytokinetic Process
Regulation Of Protein Localization To Centrosome
Protein Localization To Cleavage Furrow
Exosomal Secretion
Regulation Of Endocytic Recycling
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
Drugs
5'-Guanosine-Diphosphate-Monothiophosphate
Guanosine-5'-Diphosphate
Diseases
Alzheimer's disease (AD)
GWAS
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Mean corpuscular hemoglobin (
27863252
29403010
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
27863252
29403010
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Red blood cell count (
27863252
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
32 interacting genes:
ARF6
CHMP1B
CHMP3
DTNBP1
GDI2
IKBKG
KAT2B
MYO5A
MYO5B
OPTN
PPP2R1A
PPP2R1B
PSEN1
PSEN2
PTGIR
RAB11FIP1
RAB11FIP2
RAB11FIP3
RAB11FIP4
RAB11FIP5
RAB13
RAB3IL1
RAB3IP
RAB8A
RABGGTB
RCHY1
SEC13
SNCA
STX4
TBXA2R
TDP2
WDR44
Entrez ID
5664
8766
HPRD ID
02860
05715
Ensembl ID
ENSG00000143801
ENSG00000103769
Uniprot IDs
P49810
P62491
PDB IDs
7Y5X
7Y5Z
1OIV
1OIW
1OIX
1YZK
2D7C
2GZD
2GZH
2HV8
4C4P
4D0L
4D0M
4LWZ
4LX0
4UJ3
4UJ4
4UJ5
5C46
5C4G
5EUQ
5EZ5
5FBL
5FBQ
5FBR
5FBV
5FBW
5JCZ
6DJL
6IXV
8VOF
Enriched GO Terms of Interacting Partners
?
Cytosol
Notch Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Gamma-secretase Complex
Cytoplasm
Protein Processing
Notch Receptor Processing
Amyloid-beta Formation
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Membrane Protein Intracellular Domain Proteolysis
Protein Maturation
Cellular Response To Staurosporine
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Luteolysis
Endopeptidase Activator Activity
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Organelle Assembly
Death-inducing Signaling Complex
Amyloid Precursor Protein Metabolic Process
Amyloid-beta Metabolic Process
Execution Phase Of Apoptosis
Golgi Membrane
Proteolysis
Positive Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Membrane Protein Proteolysis
Regulation Of Autophagy
Positive Regulation Of Proteolysis
Cellular Response To Alkaloid
Organelle Organization
Angiogenesis
Negative Regulation Of Programmed Cell Death
Ovulation Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Smooth Muscle Cell Differentiation
Protein Transport
Vesicle-mediated Transport
Establishment Of Protein Localization
Intracellular Protein Localization
Recycling Endosome
Endosome
Small GTPase Binding
Recycling Endosome Membrane
Organelle Localization
Establishment Of Localization In Cell
Vesicle-mediated Transport To The Plasma Membrane
Cellular Localization
Organelle Localization By Membrane Tethering
Membrane Docking
Intracellular Transport
Negative Regulation Of Adiponectin Secretion
Endosomal Transport
Post-Golgi Vesicle-mediated Transport
Midbody
Protein Localization To Plasma Membrane
Cytosol
Exocytosis
Golgi To Plasma Membrane Transport
Protein Localization To Cell Periphery
Endocytic Recycling
Cytoplasmic Vesicle
Localization Within Membrane
Kinetochore
Golgi Vesicle Transport
Cytoplasmic Vesicle Membrane
Negative Regulation Of Cell Projection Organization
Protein Localization To Membrane
Neuron Projection
Establishment Of Protein Localization To Plasma Membrane
Golgi Apparatus
Cytoplasm
Vesicle Docking
Synaptic Vesicle
Regulation Of Protein Localization
Organelle Assembly
Organelle Organization
Regulation Of Vesicle-mediated Transport
Regulation Of Organelle Assembly
Secretion By Cell
Protein Localization To Cleavage Furrow
Endocytic Vesicle
Regulation Of Secretion By Cell
Regulation Of Receptor Recycling
Positive Regulation Of Protein Localization To Cell Periphery
Negative Regulation Of Cell Communication
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Tagcloud (Difference)
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Tagcloud (Intersection)
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