PSEN2 and ICAM5

Number of citations of the paper that reports this interaction (PubMedID 11719200)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PSEN2	ICAM5
Description		presenilin 2	intercellular adhesion molecule 5
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GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Plasma Membrane Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving	Integrin Binding Protein Binding
	Biological Process	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Phagocytosis Cell Adhesion Regulation Of Synapse Assembly Cell-cell Adhesion
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Blood protein levels ( 30072576) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 27863252)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	5 interacting genes: ACTN1 ITGAL ITGB2 PSEN1 PSEN2
Entrez ID		5664	7087
HPRD ID		02860	03509
Ensembl ID		ENSG00000143801	ENSG00000105376
Uniprot IDs		P49810	Q8N6I2 Q9UMF0
PDB IDs		7Y5X 7Y5Z	3BN3 4OI9 4OIA 4OIB
Enriched GO Terms of Interacting Partners?		Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation	Integrin AlphaL-beta2 Complex ICAM-3 Receptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Cell-cell Adhesion Cellular Extravasation Amyloid Precursor Protein Catabolic Process Neural Retina Development Kinetochore Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Integrin Complex Cell Activation Membrane Protein Proteolysis Receptor Clustering Cell Adhesion Leukocyte Cell-cell Adhesion Synaptic Membrane T Cell Activation Involved In Immune Response Negative Regulation Of Core Promoter Binding Specific Granule Membrane Cell Adhesion Molecule Binding Phagocytosis Structural Constituent Of Postsynapse Memory T Cell Extravasation Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Notch Signaling Pathway Platelet Morphogenesis Leukocyte Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neutrophil Degranulation Myeloid Leukocyte Activation Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Presynaptic Membrane Synaptic Vesicle Integrin Binding Membrane Leukocyte Activation Involved In Immune Response Cell-substrate Adhesion Cell Surface
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