PSEN2 and CASP6

Number of citations of the paper that reports this interaction (PubMedID 9990034)
53

Data Source:
HPRD (in vitro, in vivo)

		PSEN2	CASP6
Description		presenilin 2	caspase 6
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GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Activation Of Innate Immune Response Proteolysis Apoptotic Process Protein Autoprocessing Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Maturation Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Staurosporine Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation	Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	43 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 RNF31 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		5664	839
HPRD ID		02860	03321
Ensembl ID		ENSG00000143801	ENSG00000138794
Uniprot IDs		P49810	P55212
PDB IDs		7Y5X 7Y5Z	2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV 8EG5 8EG6 8F78 8F96 8F97 8F98 8F99 8F9A 8F9B 8F9C 8F9D 8FBV
Enriched GO Terms of Interacting Partners?		Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation	Regulation Of Programmed Cell Death Cytoplasm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleus Ripoptosome CD95 Death-inducing Signaling Complex Response To Stress Programmed Cell Death Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Death-inducing Signaling Complex Cytoskeleton Organization Ubiquitin Protein Ligase Binding Nuclear Matrix Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Modification Process Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Cytosol Regulation Of Protein Metabolic Process Intermediate Filament Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Macromolecule Metabolic Process Cellular Response To Stress Organelle Organization Structural Constituent Of Cytoskeleton Structural Constituent Of Nuclear Lamina Positive Regulation Of Metabolic Process Regulation Of Signaling Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Communication Response To Hypoxia Regulation Of Macroautophagy Positive Regulation Of DNA-binding Transcription Factor Activity Apolipoprotein Binding Death Receptor Binding Astrocyte Activation
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