KCNIP3 and CLN3

Number of citations of the paper that reports this interaction (PubMedID 17189291)
0

Data Source:
BioGRID (two hybrid)

		KCNIP3	CLN3
Description		potassium voltage-gated channel interacting protein 3	CLN3 lysosomal/endosomal transmembrane protein, battenin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Golgi Membrane Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Caveola Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuron Projection Autolysosome Membrane Raft Synapse Recycling Endosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Protein Binding Glycolipid Transfer Activity Calcium-dependent Protein Binding Glycolipid Binding Sulfatide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Action Potential Amino Acid Transport Endocytosis Receptor-mediated Endocytosis Lysosome Organization Lysosomal Lumen Acidification Learning Or Memory Associative Learning Intracellular Water Homeostasis Regulation Of Autophagy Regulation Of Fibroblast Migration Macroautophagy Regulation Of Autophagosome Size Protein Processing Intracellular Monoatomic Cation Homeostasis Actin Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Synaptic Transmission, GABAergic Ionotropic Glutamate Receptor Signaling Pathway Ceramide Transport Lysosomal Lumen PH Elevation Renal Potassium Excretion Amyloid Precursor Protein Catabolic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Plasma Membrane Raft Organization Negative Regulation Of Proteolysis Glycerophospholipid Biosynthetic Process Glycolipid Transport Vesicle Transport Along Microtubule Regulation Of Short-term Neuronal Synaptic Plasticity Positive Regulation Of Pinocytosis Neuromuscular Process Controlling Balance Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Filopodium Assembly Regulation Of Cytoskeleton Organization Establishment Of Localization In Cell Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Autophagosome-lysosome Fusion Regulation Of Biological Quality Regulation Of Protein Processing Protein Localization To Membrane Protein Localization To Plasma Membrane Golgi To Lysosome Transport Phagosome-lysosome Docking Phagosome-lysosome Fusion Autophagosome Maturation Regulation Of Cellular Response To Osmotic Stress Regulation Of Arginine Biosynthetic Process Regulation Of Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane L-arginine Transmembrane Transport Lysosomal Protein Catabolic Process Regulation Of Phagosome Maturation Regulation Of Modification Of Synaptic Structure Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription	Glycosphingolipid transport
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Bullous pemphigoid ( 34011352) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252) Type 1 diabetes ( 30572963)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	2 interacting genes: KCNIP3 SBDS
Entrez ID		30818	1201
HPRD ID		05232	08450
Ensembl ID		ENSG00000115041	ENSG00000188603
Uniprot IDs		Q9Y2W7	B4DFF3 B4DMY6 Q13286 Q2TA70
PDB IDs		2E6W
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process
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