KCNIP3 and CLN3

Number of citations of the paper that reports this interaction (PMID 17189291)
8

Data Source:
BioGRID (two hybrid)

		KCNIP3	CLN3
Gene Name		Kv channel interacting protein 3, calsenilin	ceroid-lipofuscinosis, neuronal 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Dendrite Protein-DNA Complex Axon Terminus	Golgi Membrane Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Plasma Membrane Caveola Synaptic Vesicle Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Neuron Projection Membrane Raft
	Molecular Function	DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein C-terminus Binding Potassium Channel Regulator Activity Sequence-specific DNA Binding Ion Channel Binding Calcium-dependent Protein Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Protein Transport Apoptotic Process Signal Transduction Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Regulation Of Neuron Apoptotic Process Behavioral Response To Pain Potassium Ion Transmembrane Transport	Autophagic Vacuole Fusion Action Potential Globoside Metabolic Process Cellular Amino Acid Metabolic Process Ceramide Metabolic Process Glucosylceramide Metabolic Process Galactosylceramide Metabolic Process Sphingomyelin Metabolic Process Receptor-mediated Endocytosis Vacuolar Transport Lysosome Organization Lysosomal Lumen Acidification Associative Learning Arginine Transport Macroautophagy Negative Regulation Of Macroautophagy Protein Processing Protein Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway Lysosomal Lumen PH Elevation Neurotransmitter Metabolic Process Amyloid Precursor Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteolysis Vesicle Transport Along Microtubule Neuromuscular Process Controlling Balance Cytosolic Calcium Ion Homeostasis Membrane Organization
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		17 interactors: ADRBK1 CALM2 CASP3 CD177 CLN3 CREB1 CREM GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2	2 interactors: KCNIP3 SBDS
Entrez ID		30818	1201
HPRD ID		05232	08450
Ensembl ID		ENSG00000115041	ENSG00000188603
Uniprot IDs		Q9Y2W7	B4DFF3 Q13286
PDB IDs		2E6W
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Negative Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Amyloid Precursor Protein Metabolic Process Regulation Of Protein Phosphorylation Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Phosphorylation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Negative Regulation Of Cellular Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Activation Of Phospholipase C Activity Negative Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Regulation Of Kinase Activity Intracellular Signal Transduction Negative Regulation Of Protein Kinase Activity Response To Stress Negative Regulation Of Kinase Activity Protein Processing Negative Regulation Of Apoptotic Process Positive Regulation Of Phospholipase Activity Negative Regulation Of Programmed Cell Death Learning Or Memory	Mitotic Spindle Stabilization Spindle Stabilization Bone Marrow Development Mature Ribosome Assembly Regulation Of Mitotic Spindle Organization Behavioral Response To Pain Inner Cell Mass Cell Proliferation Ribosomal Large Subunit Biogenesis Blastocyst Growth Ribosome Assembly Negative Regulation Of Microtubule Depolymerization Response To Pain Negative Regulation Of Microtubule Polymerization Or Depolymerization Bone Mineralization
Tagcloud ?			associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Difference) ?			associates breakdown cerevisiae chaperone cln2 close defect degradation degraded dnaj folding g1 h1 homolog inactivation nonpermissive p34cdc28 phosphorylation proper proteasome proximity pure reconstitution saccharomyces seems segment sis1 triggered ydj1
Tagcloud (Intersection) ?