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KCNIP3 and CALM2
Number of citations of the paper that reports this interaction (PMID
17189291
)
8
Data Source:
BioGRID
(two hybrid)
KCNIP3
CALM2
Gene Name
Kv channel interacting protein 3, calsenilin
calmodulin 2 (phosphorylase kinase, delta)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Dendrite
Protein-DNA Complex
Axon Terminus
Spindle Pole
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Spindle Microtubule
Plasma Membrane
Sarcomere
Growth Cone
Vesicle
Calcium Channel Complex
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Transcription Corepressor Activity
Voltage-gated Ion Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein C-terminus Binding
Potassium Channel Regulator Activity
Sequence-specific DNA Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Calcium Ion Binding
Protein Binding
Adenylate Cyclase Binding
Protein Kinase Binding
Protein Domain Specific Binding
Nitric-oxide Synthase Regulator Activity
Titin Binding
Type 3 Metabotropic Glutamate Receptor Binding
Thioesterase Binding
N-terminal Myristoylation Domain Binding
Phospholipase Binding
Protein Serine/threonine Kinase Activator Activity
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Nitric-oxide Synthase Binding
Protein Phosphatase Activator Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Sensory Perception Of Pain
Regulation Of Ion Transmembrane Transport
Regulation Of Neuron Apoptotic Process
Behavioral Response To Pain
Potassium Ion Transmembrane Transport
Response To Amphetamine
Regulation Of Heart Rate
Platelet Degranulation
Detection Of Calcium Ion
Carbohydrate Metabolic Process
Glycogen Catabolic Process
Glucose Metabolic Process
Muscle Contraction
Organelle Organization
Mitochondrion Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Activation Of Phospholipase C Activity
Synaptic Transmission
Blood Coagulation
Phototransduction, Visible Light
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Rhodopsin Mediated Signaling Pathway
Substantia Nigra Development
Regulation Of Rhodopsin Mediated Signaling Pathway
Platelet Activation
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Positive Regulation Of Protein Autophosphorylation
Regulation Of Cytokinesis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Fc-epsilon Receptor Signaling Pathway
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
Nitric Oxide Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Membrane Organization
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of High Voltage-gated Calcium Channel Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Ca-dependent events
CaM pathway
Signaling by FGFR in disease
Phospholipase C-mediated cascade
Signaling by Wnt
Platelet degranulation
Signaling by EGFRvIII in Cancer
CREB phosphorylation through the activation of Ras
PLCG1 events in ERBB2 signaling
Glucose metabolism
DAP12 signaling
Synthesis of IP3 and IP4 in the cytosol
Myoclonic epilepsy of Lafora
Response to elevated platelet cytosolic Ca2+
Glycogen storage diseases
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Activation of Ca-permeable Kainate Receptor
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Ionotropic activity of Kainate Receptors
Signaling by PDGF
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
DAP12 interactions
Glycogen breakdown (glycogenolysis)
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Diseases associated with visual transduction
Inositol phosphate metabolism
EGFR interacts with phospholipase C-gamma
CaMK IV-mediated phosphorylation of CREB
Signaling by ERBB2
Signaling by EGFR
Signaling by VEGF
CREB phosphorylation through the activation of CaMKK
Downstream signal transduction
Calmodulin induced events
CREB phosphorylation through the activation of CaMKII
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Transcriptional activation of mitochondrial biogenesis
Metabolism of carbohydrates
Platelet activation, signaling and aggregation
Adaptive Immune System
Transmission across Chemical Synapses
Ras activation uopn Ca2+ infux through NMDA receptor
Organelle biogenesis and maintenance
Cam-PDE 1 activation
Translocation of GLUT4 to the plasma membrane
VEGFA-VEGFR2 Pathway
DAG and IP3 signaling
CaM pathway
Inactivation, recovery and regulation of the phototransduction cascade
Metabolism of nitric oxide
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability
Activation of NMDA receptor upon glutamate binding and postsynaptic events
The phototransduction cascade
Downstream signaling of activated FGFR
DARPP-32 events
eNOS activation and regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
Post NMDA receptor activation events
Signalling by NGF
PLC beta mediated events
Smooth Muscle Contraction
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Mitochondrial biogenesis
beta-catenin independent WNT signaling
Signaling by FGFR
eNOS activation
Cam-PDE 1 activation
Ca2+ pathway
Visual phototransduction
Activation of CaMK IV
PLC-gamma1 signalling
FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS
Dialysis-related mortality (
21546767
)
Protein-Protein Interactions
17 interactors:
ADRBK1
CALM2
CASP3
CD177
CLN3
CREB1
CREM
GRK6
IGF1R
IGLV3-25
IL6ST
MAVS
PCBD2
PPP3CA
PSEN1
PSEN2
TARBP2
40 interactors:
ADAMTS12
ADCY8
AKAP9
ASCL2
C11orf65
CACNA1A
CALD1
CAMTA2
CCND2
DLG1
EDF1
EGFR
ESR1
ESR2
GRM5
GRM7
INSR
INVS
IQCB1
IQCE
IQGAP3
KCNIP3
KCNQ2
KCNQ3
KCNQ5
KIAA1683
MARCKS
MRPL20
MYF5
MYF6
MYO6
MYOD1
MYOG
NEUROD1
PCNT
PPEF1
PPEF2
RAB3B
RPSA
TCF4
Entrez ID
30818
805
HPRD ID
05232
00242
Ensembl ID
ENSG00000115041
ENSG00000143933
Uniprot IDs
Q9Y2W7
B4DJ51
P62158
PDB IDs
2E6W
1AJI
1CDL
1CLL
1CTR
1IWQ
1J7O
1J7P
1K90
1K93
1L7Z
1LVC
1NKF
1PK0
1S26
1SK6
1SW8
1WRZ
1XFU
1XFV
1XFW
1XFX
1XFY
1XFZ
1Y6W
1YR5
1YRT
1YRU
1ZOT
1ZUZ
2BE6
2F3Y
2F3Z
2HF5
2I08
2JZI
2K0E
2K0F
2K0J
2K61
2KNE
2KUG
2KUH
2L53
2L7L
2LGF
2LL6
2LL7
2LQC
2LQP
2LV6
2M55
2R28
2V01
2V02
2VAY
2W73
2WEL
2X0G
2Y4V
3BYA
3DVE
3DVJ
3DVK
3DVM
3EWT
3EWV
3G43
3HR4
3J41
3O77
3O78
3OXQ
3SUI
3UCT
3UCW
3UCY
4DCK
4DJC
4GOW
Enriched GO Terms of Interacting Partners
?
Amyloid Precursor Protein Catabolic Process
Regulation Of Immune System Process
Negative Regulation Of Protein Phosphorylation
Cellular Response To Organic Substance
Response To Organic Substance
Positive Regulation Of Metabolic Process
Negative Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Regulation Of Protein Phosphorylation
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Immune Response
Regulation Of Phosphorylation
Regulation Of Immune Response
Negative Regulation Of Protein Metabolic Process
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Phosphorus Metabolic Process
Signaling
Negative Regulation Of Cellular Metabolic Process
Cell Communication
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Signaling
Regulation Of Protein Kinase Activity
Activation Of Phospholipase C Activity
Negative Regulation Of Signaling
Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Phospholipase C Activity
Regulation Of Kinase Activity
Intracellular Signal Transduction
Negative Regulation Of Protein Kinase Activity
Response To Stress
Negative Regulation Of Kinase Activity
Protein Processing
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Programmed Cell Death
Learning Or Memory
Positive Regulation Of Skeletal Muscle Fiber Development
Cell-cell Signaling
Synaptic Transmission
Tissue Development
Epithelium Development
Positive Regulation Of Cellular Metabolic Process
Muscle Cell Fate Commitment
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Myoblast Fusion
Cellular Response To Estradiol Stimulus
Regulation Of Skeletal Muscle Fiber Development
Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion
Regulation Of Myoblast Fusion
Regulation Of Cellular Process
Regulation Of Skeletal Muscle Tissue Development
System Development
Organ Development
Cell Differentiation
Cellular Response To Estrogen Stimulus
Positive Regulation Of Skeletal Muscle Tissue Development
Multicellular Organismal Development
Regulation Of Signaling
Regulation Of Ion Transmembrane Transport
Organ Morphogenesis
Positive Regulation Of Myotube Differentiation
Anatomical Structure Development
Regulation Of Ion Transport
Embryonic Organ Development
Positive Regulation Of Metabolic Process
Regulation Of Myoblast Differentiation
Anatomical Structure Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Development
Response To Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Developmental Process
Generation Of Neurons
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Myotube Differentiation
Regulation Of Striated Muscle Tissue Development
Skeletal Muscle Cell Differentiation
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Striated Muscle Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Activation Of Protein Kinase Activity
Positive Regulation Of Striated Muscle Tissue Development
Positive Regulation Of Muscle Tissue Development
Negative Regulation Of Signal Transduction
Neurogenesis
Tagcloud
?
100nm
48h
81m
anapc13
carcinogenic
diarrheic
drawing
exhaustive
explanation
hn1
malat1
mapre2
mllt11
molluscs
oa
okadaic
pathologies
poisoning
positives
pttg1
rodents
sga
shellfish
shsy5y
ssh
subtractive
tax1bp1
toxins
tumourigenesis
Tagcloud (Difference)
?
100nm
48h
81m
anapc13
carcinogenic
diarrheic
drawing
exhaustive
explanation
hn1
malat1
mapre2
mllt11
molluscs
oa
okadaic
pathologies
poisoning
positives
pttg1
rodents
sga
shellfish
shsy5y
ssh
subtractive
tax1bp1
toxins
tumourigenesis
Tagcloud (Intersection)
?