PSEN2 and CTNND2

Number of citations of the paper that reports this interaction (PubMedID 10037471)
0

Data Source:
HPRD (in vivo)

		PSEN2	CTNND2
Description		presenilin 2	catenin delta 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Synaptic Vesicle Membrane Nuclear Membrane Protein-containing Complex Presynaptic Membrane Gamma-secretase Complex Synaptic Membrane	Nucleus Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Dendrite Cell Projection Perikaryon Anchoring Junction
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving	Protein Binding Beta-catenin Binding Cadherin Binding
	Biological Process	Response To Hypoxia Proteolysis Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Amyloid-beta Formation Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Calcium Ion Homeostasis Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Cell Adhesion Signal Transduction Wnt Signaling Pathway Synapse Organization Regulation Of Canonical Wnt Signaling Pathway Dendritic Spine Morphogenesis Cell-cell Adhesion
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation
Drugs
Diseases		Alzheimer's disease (AD)	Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Cannabis dependence symptom count ( 27028160) Clostridioides difficle infection ( 33841421) Cognitive performance (processing speed) ( 31598132) Common carotid intima-media thickness in HIV infection ( 29206233) Corneal astigmatism ( 30306274) Facial emotion recognition ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Lewy body disease ( 25188341) Macular thickness ( 30535121) Myopia (pathological) ( 21095009) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to antidepressants (symptom improvement) ( 29160301) Sensorimotor dexterity ( 31596458) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Systolic blood pressure ( 27841878) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	22 interacting genes: ABL1 ATN1 CDH1 CDH2 CLK1 CTNNB1 CTTN ERBIN FYN LCK LNX1 LRRC7 MAGI2 NCAM2 NUDT21 PDZD2 PSEN1 PSEN2 PTGER4 SPHK1 TBKBP1 TTR
Entrez ID		5664	1501
HPRD ID		02860	09181
Ensembl ID		ENSG00000143801	ENSG00000169862
Uniprot IDs		P49810	A0A994J5V2 B4DJU1 B4DRK2 E7EPC8 Q9UQB3
PDB IDs		7Y5X 7Y5Z
Enriched GO Terms of Interacting Partners?		Cytosol Notch Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Gamma-secretase Complex Cytoplasm Protein Processing Notch Receptor Processing Amyloid-beta Formation Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Membrane Protein Intracellular Domain Proteolysis Protein Maturation Cellular Response To Staurosporine Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Luteolysis Endopeptidase Activator Activity Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Organelle Assembly Death-inducing Signaling Complex Amyloid Precursor Protein Metabolic Process Amyloid-beta Metabolic Process Execution Phase Of Apoptosis Golgi Membrane Proteolysis Positive Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Membrane Protein Proteolysis Regulation Of Autophagy Positive Regulation Of Proteolysis Cellular Response To Alkaloid Organelle Organization Angiogenesis Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Regulation Of Protein Metabolic Process Regulation Of Smooth Muscle Cell Differentiation	Postsynapse Cell Motility Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Junction Cell Adhesion Synapse Organization T Cell Activation Cell-cell Adhesion Glutamatergic Synapse Catenin Complex Cell-cell Junction T Cell Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Migration Anchoring Junction CD8 Receptor Binding Regulation Of Cell Projection Organization Positive Regulation Of Blood Vessel Branching Lymphocyte Activation Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activity Cellular Response To Indole-3-methanol Cell-cell Adhesion Mediated By Cadherin Response To Indole-3-methanol Cell Junction Organization Detection Of Abiotic Stimulus Neuron Projection Organization Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Cellular Response To Growth Factor Stimulus Detection Of Mechanical Stimulus Detection Of Muscle Stretch Gamma-secretase Complex Response To Xenobiotic Stimulus Thymus Development Receptor Clustering Positive Regulation Of Neuron Projection Development Intracellular Signal Transduction T Cell Differentiation Regulation Of Synapse Organization Antigen Receptor-mediated Signaling Pathway Regulation Of Blood Vessel Branching Adherens Junction Organization Fascia Adherens Cytoplasm Cadherin Binding Response To Growth Factor Fc Receptor Signaling Pathway Mononuclear Cell Differentiation Activated T Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?