KCNIP3 and SOD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNIP3	SOD3
Description		potassium voltage-gated channel interacting protein 3	superoxide dismutase 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding Antioxidant Activity Oxidoreductase Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Response To Hypoxia Superoxide Metabolic Process Removal Of Superoxide Radicals
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription	Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Benzoyl peroxide
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Blood protein levels ( 30072576) Major depressive disorder ( 23377640)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	9 interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		30818	6649
HPRD ID		05232	01708
Ensembl ID		ENSG00000115041	ENSG00000109610
Uniprot IDs		Q9Y2W7	A0A140VJU8 P08294
PDB IDs		2E6W	2JLP
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Regulation Of Metal Ion Transport Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Monoatomic Ion Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Calcium Ion Binding Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Positive Regulation Of Protein Metabolic Process Intramembranous Bone Growth Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Protein Targeting To Membrane Regulation Of Transport Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Catabolic Process Autophagosome Regulation Of Potassium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Kv4.3-KChIP1 Channel Complex Autophagosome Assembly Autophagosome Organization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Monoatomic Ion Channel Complex BAT3 Complex Binding Localization Within Membrane Negative Regulation Of Clathrin-dependent Endocytosis Transmembrane Transporter Binding
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