KCNIP3 and CDSN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNIP3	CDSN
Description		potassium voltage-gated channel interacting protein 3	corneodesmosin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cell-cell Adhesion Negative Regulation Of Cornification Amyloid Fibril Formation
Pathways		Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription	Formation of the cornified envelope
Drugs
Diseases			Hypotrichosis simplex of scalp
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Systemic mastocytosis ( 32752121) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 21738480 20139978)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	37 interacting genes: ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17
Entrez ID		30818	1041
HPRD ID		05232	03998
Ensembl ID		ENSG00000115041	ENSG00000204539
Uniprot IDs		Q9Y2W7	Q15517
PDB IDs		2E6W
Enriched GO Terms of Interacting Partners?		Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding TRC Complex Protein Targeting To ER Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Endoplasmic Reticulum ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Centriole Protein Targeting To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane MRNA Cleavage And Polyadenylation Specificity Factor Complex Molecular Adaptor Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Binding Autophagosome Proteolysis Regulation Of Macroautophagy Localization Within Membrane Protein Targeting Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Cytoplasm
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