AFF4 and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		AFF4	SPP1
Gene Name		AF4/FMR2 family, member 4	secreted phosphoprotein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Transcription Elongation Factor Complex Transcriptionally Active Chromatin	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Development	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways			Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		9 interactors: AP2B1 CCNT1 CDK9 GOLGA2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		27125	6696
HPRD ID		09187	01325
Ensembl ID		ENSG00000072364	ENSG00000118785
Uniprot IDs		Q9UHB7	B7Z351 P10451 Q3LGB0
PDB IDs		4IMY	3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Replication Fork Arrest Response To Organic Substance Viral Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Collateral Sprouting Negative Regulation Of Glial Cell Apoptotic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Axon Regeneration Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Cellular Response To Nitric Oxide Regulation Of Protein Phosphorylation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Adhesion Regulation Of Protein Homodimerization Activity Locomotion Axon Guidance Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Arrest Cell Cycle	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process
Tagcloud ?		af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?		af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb	able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?