AFF4 and SIAH1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		AFF4	SIAH1
Gene Name		AF4/FMR2 family, member 4	siah E3 ubiquitin protein ligase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Transcription Elongation Factor Complex Transcriptionally Active Chromatin	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Development	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AP2B1 CCNT1 CDK9 GOLGA2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2	135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671
Entrez ID		27125	6477
HPRD ID		09187	03736
Ensembl ID		ENSG00000072364	ENSG00000196470
Uniprot IDs		Q9UHB7	Q8IUQ4
PDB IDs		4IMY	2A25 4I7B 4I7C 4I7D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Replication Fork Arrest Response To Organic Substance Viral Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Collateral Sprouting Negative Regulation Of Glial Cell Apoptotic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Axon Regeneration Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Cellular Response To Nitric Oxide Regulation Of Protein Phosphorylation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Adhesion Regulation Of Protein Homodimerization Activity Locomotion Axon Guidance Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Arrest Cell Cycle	Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization
Tagcloud ?		af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb	alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin
Tagcloud (Difference) ?		af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb	alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin
Tagcloud (Intersection) ?