AFF4 and BTG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		AFF4	BTG3
Description		ALF transcription elongation factor 4	BTG anti-proliferation factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Nuclear Body Super Elongation Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Spermatid Development Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Waist circumference adjusted for body mass index ( 34021172)	Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		10 interacting genes: AP2B1 BTG3 CCNT1 CDK9 GOLGA2 LRRK2 MLLT1 SIAH1 SPP1 TRAF2	76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592
Entrez ID		27125	10950
HPRD ID		09187	10415
Ensembl ID		ENSG00000072364	ENSG00000154640
Uniprot IDs		Q9UHB7	Q14201 Q6IAU3
PDB IDs		4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80
Enriched GO Terms of Interacting Partners?		P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Transcription Elongation Factor Complex Protein Kinase Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Clathrin Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury TORC2 Complex Disassembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Modification Process Negative Regulation Of Catabolic Process Positive Regulation Of Estradiol Secretion TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Protein Modification Process Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Side Of Plasma Membrane Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagy Canonical Wnt Signaling Pathway Regulation Of Estradiol Secretion Positive Regulation Of Protein Autoubiquitination Response To Curcumin Signal Sequence Binding Chromatin Binding Regulation Of Protein Serine/threonine Kinase Activity	Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone
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