AFF4 and CCNT1

Number of citations of the paper that reports this interaction (PubMedID 12065898)
0

Data Source:
HPRD (in vivo)

		AFF4	CCNT1
Description		ALF transcription elongation factor 4	cyclin T1
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GO Annotations	Cellular Component	Euchromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Nuclear Body Super Elongation Complex	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity SnRNA Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Spermatid Development Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Division
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Waist circumference adjusted for body mass index ( 34021172)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		10 interacting genes: AP2B1 BTG3 CCNT1 CDK9 GOLGA2 LRRK2 MLLT1 SIAH1 SPP1 TRAF2	24 interacting genes: AFF4 AHR BRD4 CDK9 ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2
Entrez ID		27125	904
HPRD ID		09187	03938
Ensembl ID		ENSG00000072364	ENSG00000129315
Uniprot IDs		Q9UHB7	A8K4M5 O60563
PDB IDs		4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80	2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R
Enriched GO Terms of Interacting Partners?		P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Transcription Elongation Factor Complex Protein Kinase Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Clathrin Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury TORC2 Complex Disassembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Modification Process Negative Regulation Of Catabolic Process Positive Regulation Of Estradiol Secretion TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Protein Modification Process Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Side Of Plasma Membrane Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagy Canonical Wnt Signaling Pathway Regulation Of Estradiol Secretion Positive Regulation Of Protein Autoubiquitination Response To Curcumin Signal Sequence Binding Chromatin Binding Regulation Of Protein Serine/threonine Kinase Activity	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression 7SK SnRNA Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Transcription Elongation Factor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process P-TEFb Complex Binding 7SK SnRNP Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA-templated Transcription Rhythmic Process Transcription Regulator Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Protein-containing Complex Positive Regulation Of Fibroblast Proliferation
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