Wiki-Pi
About
Search
People
Updates
Search
EZH2 and H3-4
Number of citations of the paper that reports this interaction (PubMedID
24457600
)
57
Data Source:
BioGRID
(enzymatic study, enzymatic study, enzymatic study)
EZH2
H3-4
Description
enhancer of zeste 2 polycomb repressive complex 2 subunit
H3.4 histone, cluster member
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromatin Silencing Complex
Chromosome
Pericentric Heterochromatin
ESC/E(Z) Complex
Pronucleus
Synapse
Chromosome, Telomeric Region
Nucleosome
Heterochromatin
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Chromosome
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Transcription Corepressor Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Transferase Activity
Chromatin DNA Binding
Nucleosome Binding
Histone Methyltransferase Activity
Histone Binding
Ribonucleoprotein Complex Binding
Sequence-specific DNA Binding
Histone H3K27 Methyltransferase Activity
Primary MiRNA Binding
LncRNA Binding
Histone H3 Methyltransferase Activity
Histone H3K27 Trimethyltransferase Activity
Promoter-specific Chromatin Binding
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
DNA Methylation-dependent Constitutive Heterochromatin Formation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Gliogenesis
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Cardiac Muscle Hypertrophy In Response To Stress
Cerebellar Cortex Development
Hippocampus Development
Hemopoiesis
B Cell Differentiation
Keratinocyte Differentiation
Positive Regulation Of Cell Migration
Regulatory NcRNA-mediated Heterochromatin Formation
Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Methylation
Response To Estradiol
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Trichostatin A
Protein Modification Process
Hepatocyte Homeostasis
Regulation Of Cell Population Proliferation
Regulation Of Circadian Rhythm
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Negative Regulation Of Epidermal Cell Differentiation
Negative Regulation Of Keratinocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Rhythmic Process
Stem Cell Differentiation
Regulation Of Neurogenesis
Negative Regulation Of Striated Muscle Cell Differentiation
Synaptic Transmission, GABAergic
Cellular Response To Hydrogen Peroxide
G1 To G0 Transition
Protein Localization To Chromatin
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Kidney Development
Liver Regeneration
Facultative Heterochromatin Formation
Positive Regulation Of Dendrite Development
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cell Cycle G1/S Phase Transition
Response To Tetrachloromethane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Stem Cell Differentiation
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Chromatin Assembly
Spermatogonial Cell Division
Regulation Of Cell Differentiation
Pathways
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Regulation of PD-L1(CD274) transcription
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Meiotic recombination
Inhibition of DNA recombination at telomere
Drugs
Tazemetostat
CPI-1205
Diseases
GWAS
Chronotype (
30696823
)
Colorectal or endometrial cancer (
26621817
)
Crohn's disease (
28067908
)
Familial squamous cell lung carcinoma (
29924316
)
Height (
25282103
31562340
)
Inflammatory bowel disease (
28067908
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
25673412
)
Interacting Genes
87 interacting genes:
AKT1
AR
ARID1A
ATP1A1
ATP1B1
ATRX
BCL11A
BRCA1
C7orf25
CCDC85B
CDK6
CDKN2B-AS1
CEP63
CRY2
DANCR
DELEC1
DNAJB11
DNMT1
DNMT3A
DNMT3B
E2F6
EED
EHMT1
EP300
EPC2
FBXW7
GADD45G
GTF3C1
H1-1
H2AC4
H3-4
H3C1
HAT1
HDAC1
HOTAIR
HOXA11-AS
JAK2
KAT2B
KLHDC2
KRTAP10-9
LATS2
LINC00511
MAP3K20
MAP3K7
MAPK8IP2
MAPKAPK3
MED1
MELK
MUC1
NINL
PFDN1
PHB2
PHF1
PIN4
PJA1
POLA2
PRDM14
PRMT5
PSMB6
RASA1
RBL2
RCN3
RELA
RELB
RIN3
RPN2
RPS6KA5
SIRT1
SKIC8
SMARCA4
SMARCB1
SMN1
SMS
SMYD3
SUV39H1
SUZ12
TAF1D
TK1
TNFSF11
TRIM55
TRIM63
TSPYL2
UCA1
USP1
VAV1
WSB2
ZMYND11
195 interacting genes:
ADNP
AFF1
AHDC1
ANP32A
ASF1A
ASH2L
ATAD2
AURKA
AURKB
BACC1
BIRC5
BMI1
BPTF
BRD7
CBX1
CBX2
CBX3
CBX4
CBX5
CBX7
CBX8
CDYL
CDYL2
CHAF1A
CHAF1B
CHAMP1
CHD1
CHD4
CHD6
CHUK
COPRS
CREBBP
CTBP1
CTBP2
DCAF1
DEK
DNMT1
DOT1L
DPF2
DPY30
DYRK2
EGFR
EHMT1
EHMT2
EMSY
EP300
ERAP1
EZH2
FOXA1
GADD45A
GATAD1
GLYR1
GTF3C4
HAT1
HDAC1
HDAC2
HDAC8
HIRIP3
HMGXB4
HNRNPA1
HNRNPA2B1
HNRNPAB
HNRNPL
HNRNPR
HPF1
ING2
ING4
IRAK1
JADE2
JADE3
JAK1
JAK2
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM1B
KDM2A
KDM3B
KDM5A
KDM5D
KDM6A
KIF2A
KIF2C
KMT2C
KPNA1
LRIF1
LRWD1
MBD3
MCM2
MCM7
MDM2
MEN1
MGA
MIER1
MLLT1
MORF4L1
MSL3
MTA1
MTA2
MYB
NAP1L4
NASP
NBN
NCL
NCOA2
NCOA3
NOC2L
NONO
NPM1
NSD1
NSD2
ORC2
ORC3
ORC4
ORC5
PARP1
PARP2
PCGF6
PHC2
PHC3
PHF12
PHF7
PHF8
PHRF1
PIM1
POGZ
PPIB
PPM1G
PRDM2
PRKCA
PRMT5
PTBP1
PTMA
RAG1
RBBP4
RBBP5
RBBP7
RBP5
RCOR1
RING1
RIPPLY1
RNF2
RPS6KA3
RPS6KA5
RREB1
SAP30
SET
SETD2
SETD7
SETDB1
SFPQ
SGF29
SIN3A
SIN3B
SMN1
SMNDC1
SMYD3
SUPT20H
SUPT3H
SUV39H1
SUZ12
TADA1
TADA3
TAF1
TAF10
TAF11
TAF12
TAF13
TAF15
TAF1A
TAF2
TAF3
TAF4
TAF4B
TAF5
TAF5L
TAF6
TAF6L
TAF7
TAF8
TAF9
TAF9B
TBP
TCF19
TDRD3
TNPO1
TRPM7
UHRF1
WDR5
ZMYM4
ZMYND11
ZNF217
ZNF516
Entrez ID
2146
8290
HPRD ID
03342
04156
Ensembl ID
ENSG00000106462
ENSG00000168148
Uniprot IDs
A0A090N8E9
F2YMM1
Q15910
S4S3R8
Q16695
PDB IDs
4MI0
4MI5
5GSA
5H14
5H15
5H17
5H19
5H24
5H25
5HYN
5IJ7
5IJ8
5LS6
5U5T
5U62
5WG6
5WUK
6C23
6C24
6LO2
6P5L
6U4Y
6WKR
7AT8
7QJG
7QJU
7QK4
8EQV
8FYH
8T9G
8TAS
8TB9
8VMI
8VML
8VNV
8VNZ
9C8U
9DCH
2V1D
2YBP
2YBS
3A6N
3T6R
4V2V
4V2W
6OIE
6WAT
6WAU
8VMI
8Z50
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Epigenetic Regulation Of Gene Expression
Chromatin Remodeling
Negative Regulation Of Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Heterochromatin Formation
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
P53 Binding
Nucleus
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Nucleosome Organization
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Facultative Heterochromatin Formation
Protein-containing Complex
Heterochromatin
Regulation Of DNA-templated Transcription
Regulation Of Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Constitutive Heterochromatin Formation
Chromatin Binding
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Protein-DNA Complex Assembly
Chromosome
Transferase Activity
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
DNA (cytosine-5-)-methyltransferase Activity
Chromatin Silencing Complex
Negative Regulation Of Cell Cycle
DNA Binding
Protein Modification Process
Chromatin DNA Binding
Positive Regulation Of Gene Expression
Chromatin Organization
Chromatin Remodeling
Nucleoplasm
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Epigenetic Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Histone Binding
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Chromatin
Positive Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Transcription Factor TFIID Complex
Chromosome
Protein-DNA Complex Assembly
Nucleic Acid Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Factor TFTC Complex
Negative Regulation Of Gene Expression, Epigenetic
SAGA Complex
MRNA Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
RNA Polymerase II Preinitiation Complex Assembly
Transcription Coactivator Activity
Chromosome, Telomeric Region
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?