EZH2 and SMS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EZH2	SMS
Gene Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	spermine synthase
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)	Spermidine Synthase Activity Spermine Synthase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Metabolism of polyamines Metabolism of amino acids and derivatives
Drugs			Spermine
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11	5 interactors: EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3
Entrez ID		2146	6611
HPRD ID		03342	02115
Ensembl ID		ENSG00000106462	ENSG00000102172
Uniprot IDs		Q15910 S4S3R8	B4DE40 P52788
PDB IDs		2C6V 4MI0	3C6K 3C6M
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction	MAPK Cascade Signal Transduction By Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stress Positive Regulation Of Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Nonassociative Learning Macropinocytosis Phosphate-containing Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature
Tagcloud (Intersection) ?