EZH2 and TNFSF11

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		EZH2	TNFSF11
Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	TNF superfamily member 11
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin ESC/E(Z) Complex Pronucleus Synapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Chromatin DNA Binding Nucleosome Binding Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Histone H3K27 Methyltransferase Activity Primary MiRNA Binding LncRNA Binding Histone H3 Methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Promoter-specific Chromatin Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Cerebellar Cortex Development Hippocampus Development Hemopoiesis B Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Regulatory NcRNA-mediated Heterochromatin Formation Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Response To Estradiol Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Trichostatin A Protein Modification Process Hepatocyte Homeostasis Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Stem Cell Differentiation Regulation Of Neurogenesis Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission, GABAergic Cellular Response To Hydrogen Peroxide G1 To G0 Transition Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kidney Development Liver Regeneration Facultative Heterochromatin Formation Positive Regulation Of Dendrite Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Cell Communication Cell Surface Receptor Signaling Pathway JNK Cascade Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Differentiation Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tooth Eruption Bone Resorption Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium Ion Homeostasis Bone Development Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Tazemetostat CPI-1205	Lenalidomide AMGN-0007 Denosumab Thiocolchicoside
Diseases		None	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Chronotype ( 30696823 ) Colorectal or endometrial cancer ( 26621817 ) Crohn's disease ( 28067908 ) Familial squamous cell lung carcinoma ( 29924316 ) Height ( 25282103 31562340 ) Inflammatory bowel disease ( 28067908 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 )	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic rhinitis ( 30013184 ) Arthritis (juvenile idiopathic) ( 33106285 ) Asthma (childhood onset) ( 30929738 ) Bone mineral density ( 23437003 24249740 ) Bone mineral density (paediatric, total body less head) ( 24945404 ) Bone mineral density (paediatric, upper limb) ( 24945404 ) C-reactive protein levels ( 24763700 ) Cortical thickness ( 22792071 ) Crohn's disease ( 21102463 ) Heel bone mineral density ( 30598549 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Serum alkaline phosphatase levels ( 33547301 29403010 ) Vitiligo ( 27723757 )
Interacting Genes		87 interacting genes: AKT1 AR ARID1A ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK6 CDKN2B-AS1 CEP63 CRY2 DANCR DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EP300 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H2AC4 H3-4 H3C1 HAT1 HDAC1 HOTAIR HOXA11-AS JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 LINC00511 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RCN3 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SKIC8 SMARCA4 SMARCB1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 TSPYL2 UCA1 USP1 VAV1 WSB2 ZMYND11	32 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA OLFM4 PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A UPK2 ZC3HC1
Entrez ID		2146	8600
HPRD ID		03342	04031
Ensembl ID		ENSG00000106462	ENSG00000120659
Uniprot IDs		A0A090N8E9 F2YMM1 Q15910 S4S3R8	O14788 Q54A98 Q5T9Y4
PDB IDs		4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6LO2 6P5L 6U4Y 6WKR 7AT8 7QJG 7QJU 7QK4 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	3URF 5BNQ
GO Terms Enriched among Interactors		Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process P53 Binding Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Facultative Heterochromatin Formation Protein-containing Complex Heterochromatin Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Chromatin Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Chromosome Transferase Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Multicellular Organismal Process DNA (cytosine-5-)-methyltransferase Activity Chromatin Silencing Complex Negative Regulation Of Cell Cycle DNA Binding Protein Modification Process Chromatin DNA Binding Positive Regulation Of Gene Expression	Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Response To Tumor Necrosis Factor Response To Lipid Membrane Protein Proteolysis Endopeptidase Activity Metalloendopeptidase Activity Cellular Response To Tumor Necrosis Factor Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Catalytic Activity Response To UV-A Response To DsRNA Response To Epidermal Growth Factor MAP Kinase Activity Metallopeptidase Activity Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Regulation Of Lipid Transport Epidermal Growth Factor Receptor Signaling Pathway Response To Amino Acid Starvation Cytokine-mediated Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Cholesterol Biosynthetic Process Membrane Protein Ectodomain Proteolysis I-kappaB/NF-kappaB Complex Interleukin-34-mediated Signaling Pathway Stress-activated MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Stress Stress-activated Protein Kinase Signaling Cascade Regulation Of Steroid Biosynthetic Process Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Positive Regulation Of Defense Response Protein Metabolic Process Regulation Of Golgi Inheritance Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Starvation Regulation Of Cholesterol Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Response To Mechanical Stimulus Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process