EZH2 and PHF1

Number of citations of the paper that reports this interaction (PMID 18285464)
58

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		EZH2	PHF1
Gene Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	PHD finger protein 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center ESC/E(Z) Complex Site Of Double-strand Break
	Molecular Function	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)	Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11	22 interactors: ATXN7L1 BIRC7 CALCOCO2 EZH2 HIST1H3A HIST1H3B HIST1H3C HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HSD17B14 NAB2 NEK6 PDLIM7 RBPMS TFCP2 THAP1 TRIM23 VAC14
Entrez ID		2146	5252
HPRD ID		03342	04195
Ensembl ID		ENSG00000106462	ENSG00000112511
Uniprot IDs		Q15910 S4S3R8	O43189
PDB IDs		2C6V 4MI0	2E5P 2M0O 4HCZ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Silencing DNA Methylation Chromatin Silencing Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Methylation DNA Conformation Change Wound Healing Blood Coagulation Hemostasis Response To Wounding Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Body Fluid Levels Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Protein Complex Assembly DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Component Assembly Regulation Of RNA Metabolic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	12e8 albeit at180 axon dendrite enter enters fyn glutamic map2 p301l pseudophosphorylated pseudophosphorylation replacements s235 s262 s356 s396 s404 s422 shaft shares spine spines synaptosomal t231 tau tau1 vastly
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	12e8 albeit at180 axon dendrite enter enters fyn glutamic map2 p301l pseudophosphorylated pseudophosphorylation replacements s235 s262 s356 s396 s404 s422 shaft shares spine spines synaptosomal t231 tau tau1 vastly
Tagcloud (Intersection) ?