EZH2 and HAT1

Number of citations of the paper that reports this interaction (PubMedID 34564701)
52

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		EZH2	HAT1
Description		enhancer of zeste 2 polycomb repressive complex 2 subunit	histone acetyltransferase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin ESC/E(Z) Complex Pronucleus Synapse	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Chromatin DNA Binding Nucleosome Binding Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Histone H3K27 Methyltransferase Activity Primary MiRNA Binding LncRNA Binding Histone H3 Methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Promoter-specific Chromatin Binding	Histone Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Cerebellar Cortex Development Hippocampus Development Hemopoiesis B Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Regulatory NcRNA-mediated Heterochromatin Formation Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Response To Estradiol Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Trichostatin A Protein Modification Process Hepatocyte Homeostasis Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Stem Cell Differentiation Regulation Of Neurogenesis Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission, GABAergic Cellular Response To Hydrogen Peroxide G1 To G0 Transition Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kidney Development Liver Regeneration Facultative Heterochromatin Formation Positive Regulation Of Dendrite Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Differentiation	Chromatin Organization Nucleosome Assembly Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Chromosome Organization
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	HATs acetylate histones
Drugs		Tazemetostat CPI-1205
Diseases
GWAS		Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		87 interacting genes: AKT1 AR ARID1A ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK6 CDKN2B-AS1 CEP63 CRY2 DANCR DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EP300 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H2AC4 H3-4 H3C1 HAT1 HDAC1 HOTAIR HOXA11-AS JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 LINC00511 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RCN3 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SKIC8 SMARCA4 SMARCB1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 TSPYL2 UCA1 USP1 VAV1 WSB2 ZMYND11	23 interacting genes: ACAA1 CEBPA EZH2 H2AC20 H3-4 H3C1 H4C14 H4C16 HTR2B KANK4 MEOX2 MORN5 PRKAA2 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		2146	8520
HPRD ID		03342	04339
Ensembl ID		ENSG00000106462	ENSG00000128708
Uniprot IDs		A0A090N8E9 F2YMM1 Q15910 S4S3R8	A0AAG2UVM1 O14929
PDB IDs		4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6LO2 6P5L 6U4Y 6WKR 7AT8 7QJG 7QJU 7QK4 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	2P0W 6VO5 9MJG
Enriched GO Terms of Interacting Partners?		Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process P53 Binding Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Facultative Heterochromatin Formation Protein-containing Complex Heterochromatin Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Chromatin Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Chromosome Transferase Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Multicellular Organismal Process DNA (cytosine-5-)-methyltransferase Activity Chromatin Silencing Complex Negative Regulation Of Cell Cycle DNA Binding Protein Modification Process Chromatin DNA Binding Positive Regulation Of Gene Expression	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Chromosome, Telomeric Region Protein-DNA Complex Assembly DNA Binding Nucleosome Assembly Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Cell Differentiation Sequence-specific DNA Binding Chromatin Remodeling Chromosome Nucleosome Organization Telomere Organization Protein Localization To Chromatin Chromatin Organization Regulation Of Cell Differentiation Nucleus Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Developmental Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein-containing Complex Cardiac Muscle Hypertrophy Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Hypertrophy Regulation Of Cell Development Positive Regulation Of Cartilage Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Acetate CoA-transferase Activity Phenylacetate Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Chromosome Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Coated Vesicle Membrane
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