JRK and TPM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JRK	TPM4
Description		Jrk helix-turn-helix protein	tropomyosin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Stress Fiber Podosome Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Nucleic Acid Binding DNA Binding MRNA Binding Protein Binding	Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Platelet Formation
Pathways			Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Urinary tract infection frequency ( 28928442)	Longevity ( 33657282) Mean platelet volume ( 22139419 22423221 27863252 31080455 32888494) Platelet count ( 22139419 22423221 26805783 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		36 interacting genes: ALAS1 BYSL CATSPERT CCDC136 CCDC57 CDC37 CNKSR3 FAM161A FBXO17 GOLGA6L9 HSF2BP IFRD2 KDM1A KPNA6 LDOC1 LGALS14 MTUS2 PDZD4 PICK1 PRICKLE1 TFIP11 TPM4 TRIM23 TRIM41 TRIP10 TSGA10 TXK USP2 UTP14C ZBTB8A ZNF343 ZNF417 ZNF620 ZNF629 ZNF655 ZRANB1	12 interacting genes: DANCR ISG15 JRK LNX1 NOD2 PACSIN1 PDE4B PICK1 SNAPIN TCERG1 TRIP6 USP7
Entrez ID		8629	7171
HPRD ID		04442	11734
Ensembl ID		ENSG00000234616	ENSG00000167460
Uniprot IDs		O75564	A0A2R8Y5V9 K7ENT6 P67936 V9HW56
PDB IDs
Enriched GO Terms of Interacting Partners?			Synaptic Vesicle Regulation Of Cell Communication Vesicle-mediated Transport In Synapse Regulation Of Signaling Cellular Response To Epinephrine Stimulus Regulation Of Vesicle-mediated Transport Response To Epinephrine Regulation Of Transport Regulation Of Autophagy Regulation Of Establishment Of Protein Localization Cytoplasm Ciliary Base Intracellular Protein Transport Modulation Of Chemical Synaptic Transmission Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Nutrient Levels Developmental Maturation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Late Endosome To Lysosome Transport Presynaptic Endocytic Zone Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Regulation Of Gluconeogenesis Regulation Of Interleukin-2 Production Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Intracellular Transport TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Ubiquitination Regulation Of Interleukin-10 Production Negative Regulation Of TORC1 Signaling Protein-containing Complex Localization Membrane Organization Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Type II Interferon Production Negative Regulation Of Relaxation Of Cardiac Muscle Detection Of Peptidoglycan Intracellular Protein Localization Protein Localization To Membrane Regulation Of Cardiac Muscle Contraction Regulation Of Endocytosis Protein Modification By Small Protein Conjugation Perinuclear Region Of Cytoplasm Phagocytic Vesicle TOR Signaling Neuron Projection Cytosol Negative Regulation Of TOR Signaling
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