JRK and TXK

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		JRK	TXK
Name		Jrk helix-turn-helix protein	TXK tyrosine kinase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding MRNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Protein Phosphorylation Regulation Of Gene Expression Positive Regulation Of Type II Interferon Production Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway
Pathways		None	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		None	Fostamatinib Zanubrutinib
GWAS		Urinary tract infection frequency ( 28928442 )	Aspartate aminotransferase levels ( 33547301 ) Crohn's disease ( 23128233 ) Mean platelet volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Platelet distribution width ( 27863252 32888494 )
Novel Interactors		1 novel interactors: LY6E	2 novel interactors: TEC UTP18
Interacting Genes		36 interacting genes: ALAS1 BYSL CATSPERT CCDC136 CCDC57 CDC37 CNKSR3 FAM161A FBXO17 GOLGA6L9 HSF2BP IFRD2 KDM1A KPNA6 LDOC1 LGALS14 MTUS2 PDZD4 PICK1 PRICKLE1 TFIP11 TPM4 TRIM23 TRIM41 TRIP10 TSGA10 TXK USP2 UTP14C ZBTB8A ZNF343 ZNF417 ZNF620 ZNF629 ZNF655 ZRANB1	38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		8629	7294
HPRD ID		04442	02505
Ensembl ID		ENSG00000234616	ENSG00000074966
Uniprot IDs		O75564	P42681
PDB IDs		Not available	2DM0
GO Terms Enriched among Interactors		None	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphotyrosine Residue Binding ErbB-3 Class Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Basal Plasma Membrane Leukocyte Activation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Kinase Activity Cell Activation Signal Transduction Negative Regulation Of Immune System Process Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Ephrin Receptor Signaling Pathway Receptor Complex ERBB3:ERBB2 Complex Peptidyl-tyrosine Phosphorylation T Cell Activation Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Kinase Activity Immune System Process Regulation Of Cell Adhesion Schwann Cell Development Regulation Of Cell Activation Leukocyte Migration Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation Neuregulin Receptor Activity Regulation Of MAPK Cascade Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Scaffold Protein Binding Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Migration