JRK and PRICKLE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JRK	PRICKLE1
Description		Jrk helix-turn-helix protein	prickle planar cell polarity protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding DNA Binding MRNA Binding Protein Binding	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways			Asymmetric localization of PCP proteins
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Urinary tract infection frequency ( 28928442)	Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		36 interacting genes: ALAS1 BYSL CATSPERT CCDC136 CCDC57 CDC37 CNKSR3 FAM161A FBXO17 GOLGA6L9 HSF2BP IFRD2 KDM1A KPNA6 LDOC1 LGALS14 MTUS2 PDZD4 PICK1 PRICKLE1 TFIP11 TPM4 TRIM23 TRIM41 TRIP10 TSGA10 TXK USP2 UTP14C ZBTB8A ZNF343 ZNF417 ZNF620 ZNF629 ZNF655 ZRANB1	7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP
Entrez ID		8629	144165
HPRD ID		04442	16341
Ensembl ID		ENSG00000234616	ENSG00000139174
Uniprot IDs		O75564	B3KVG3 B3KVG6 Q96MT3
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?