SNRPB2 and SMN2

Number of citations of the paper that reports this interaction (PMID 9323129)
127

Data Source:
HPRD (in vitro)

		SNRPB2	SMN2
Gene Name		small nuclear ribonucleoprotein polypeptide B	survival of motor neuron 2, centromeric
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U2 SnRNP Nucleolus Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Nucleotide Binding Protein Binding SnRNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALM1 DHX9 GABPB1 GOLGA2 HMBOX1 HNRNPUL1 HOMEZ HTATSF1 MCM6 MTUS2 PNMA1 SMN2 SNRPA1 SUGP1 TRIM27 ZBTB14	24 interactors: BLOC1S6 BYSL CHTOP DDX20 DHX9 FAM9B FBL GAR1 GEMIN2 HNRNPUL1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG TIAL1 VPS28
Entrez ID		6629	6607
HPRD ID		04628	09036
Ensembl ID		ENSG00000125870	ENSG00000205571
Uniprot IDs		P08579	B4DP61 Q16637
PDB IDs		1A9N	1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Processing MRNA Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity CRD-mediated MRNA Stabilization Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Import Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Nitrogen Compound Metabolic Process Interferon-gamma Secretion Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Immune Response Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Detection Of Calcium Ion Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity DNA Unwinding Involved In DNA Replication	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly RNA Splicing RNA Processing MRNA Processing Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process MRNA Metabolic Process Ribonucleoprotein Complex Assembly RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Spliceosomal Complex Assembly Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Termination Cellular Macromolecular Complex Assembly Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing RNA 3'-end Processing Cellular Metabolic Process Cellular Component Assembly Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RRNA Processing RRNA Metabolic Process Metabolic Process Ribosome Biogenesis Histone Glutamine Methylation Cellular Process Transcription, RNA-templated Peptidyl-glutamine Methylation Positive Regulation Of Type I Interferon Production Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway DNA-templated Transcription, Elongation SnoRNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process CRD-mediated MRNA Stabilization Regulation Of Type I Interferon Production Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Helicase Activity Secretion Of Lysosomal Enzymes Late Endosome To Vacuole Transport Osteoblast Differentiation
Tagcloud ?		acetyltransferase aggregates als amyotrophic anacardic candidates carry cytoskeletal cytosolic degenerate detergent elucidating familial fatal generate hampered insoluble ipsc ipscs motor neurites neuron neurons pluripotent postmortem rescued spliceosomal tar zebrafish	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness
Tagcloud (Difference) ?		acetyltransferase aggregates als amyotrophic anacardic candidates carry cytoskeletal cytosolic degenerate detergent elucidating familial generate hampered insoluble ipsc ipscs motor neurites neuron neurons pluripotent postmortem rescued spliceosomal tar zebrafish	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness
Tagcloud (Intersection) ?		fatal