SNRPB2 and DHX9

Number of citations of the paper that reports this interaction (PubMedID 11149922)
78

Data Source:
HPRD (in vivo)

		SNRPB2	DHX9
Description		small nuclear ribonucleoprotein polypeptide B2	DExH-box helicase 9
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP Nuclear Speck Cytoplasmic Ribonucleoprotein Granule U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Spliceosomal SnRNP Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U1 SnRNA Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding Ribosome Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding RNA Polymerase Binding Catalytic Activity, Acting On A Nucleic Acid RISC Complex Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	Alternative MRNA Splicing, Via Spliceosome Osteoblast Differentiation Immune System Process DNA Replication Chromatin Organization DNA-templated Transcription Termination Regulation Of Transcription By RNA Polymerase II MRNA Processing Regulation Of Translation Inflammatory Response RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing DNA-templated Viral Transcription Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Protein-containing Complex Assembly Pyroptotic Inflammatory Response RISC Complex Assembly CRD-mediated MRNA Stabilization Cellular Response To Exogenous DsRNA Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation
Pathways		mRNA Splicing - Major Pathway	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling
Drugs
Diseases
GWAS		Food allergy (maternal genetic effects) ( 29489655) Metabolite levels ( 23823483) Response to haloperidol in schizophrenia ( 29503163)
Interacting Genes		26 interacting genes: ALAS1 CALM1 CEBPA CMTM6 DHX9 ERBB3 FOXP1 GABPB1 GABPB2 GOLGA2 HMBOX1 HNRNPUL1 HOMEZ HTATSF1 MCM6 MTUS2 NAP1L5 PICK1 PNMA1 PTEN SMN2 SNRPA1 SUGP1 TRIM23 TRIM27 ZBTB14	44 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DUX4 GEMIN2 GEMIN4 GTF2B HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01016 LINC01554 MBD2 NXF1 OGA OGT PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA RNF10 RNF168 SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I USP7 YWHAQ
Entrez ID		6629	1660
HPRD ID		04628	04386
Ensembl ID		ENSG00000125870	ENSG00000135829
Uniprot IDs		P08579	B3KU66 Q08211
PDB IDs		1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7EVO 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 9FMD	3LLM 3VYX 3VYY 8SZP
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleoplasm Nucleus RNA Splicing RNA Splicing, Via Transesterification Reactions Single-stranded 3'-5' DNA Helicase Activity RISC Complex Binding MRNA Metabolic Process CRD-mediated MRNA Stability Complex MRNA Processing Spliceosomal Complex Assembly Importin-alpha Family Protein Binding CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Stem-loop Binding Cytoplasmic Ribonucleoprotein Granule Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Meiotic Spindle Assembly Positive Regulation Of Cytoplasmic Translation DNA-templated Transcription Termination Regulation Of Viral Transcription Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Meiotic Spindle Organization Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome PML Body U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Dendritic Spine Organization Response To Stress Protein Binding Positive Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding 3'-5' DNA/RNA Helicase Activity Regulation Of Cytoplasmic Translation DNA-templated Viral Transcription Regulatory Region RNA Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Organ Growth Regulation Of Actin Nucleation Telomere-telomerase Complex Assembly DNA Helicase Activity RNA Processing Nucleic Acid Binding	RNA Splicing Nucleoplasm MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process Nucleus RNA Binding SMN-Sm Protein Complex Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Assembly Macromolecule Metabolic Process RNA Processing SMN Complex Gemini Of Cajal Bodies RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Protein-RNA Complex Assembly Spliceosomal Complex Assembly Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process MRNA Binding Protein-containing Complex Assembly Ribonucleoprotein Complex Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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