TTC23 and ADCY4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTC23	ADCY4
Description		tetratricopeptide repeat domain 23	adenylate cyclase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium Cell Projection	Cytoplasm Plasma Membrane Membrane Dendrite
	Molecular Function	Protein Binding	Nucleotide Binding Adenylate Cyclase Activity Protein Kinase C Binding Protein Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Smoothened Signaling Pathway	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction
Pathways			Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Colforsin
Diseases
GWAS		Bell's palsy ( 33602968)	Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		99 interacting genes: ABI1 ADCY4 AIRIM ALAS1 APP BANP BHLHE40 BLZF1 CBX8 CCDC102B CCDC24 CCNDBP1 CDK18 CDR2 CNTROB CREBZF CYSRT1 DISC1 EFCAB3 FAM161B FSD2 GOLGA2 GOLGA6L9 GPANK1 GPRASP2 GRIPAP1 HOOK2 HSF2BP HTT INSC KASH5 KDM1A KIAA1328 KLHL42 KRT15 KRT16 KRT27 KRT31 KRT34 KRT36 KRT40 KRTAP10-3 KRTAP10-8 LCN2 LDOC1 LZTS2 MAGED1 MBD3 MDFI MED12L MESD MID2 MKRN3 MTUS2 NOTO NUTM1 PICK1 PIH1D2 PLEKHG4 PNMA1 PNMA5 POLR2J3 POU6F2 PPP1R16A PRDM6 PRKAB2 PRPH PSORS1C2 RAD51D RBCK1 SPAG11B SPAG5 SPAG8 SPDEF SSX2IP TADA2A TEX13A TLE5 TRAF2 TRAPPC6A TRIB3 TRIM10 TRIM32 TRIM54 TRIM73 TRIP6 TSGA10IP UBXN11 USHBP1 XIAP XRN2 ZBED1 ZBTB16 ZBTB42 ZDHHC17 ZFHX3 ZFYVE26 ZIM2 ZRANB1	5 interacting genes: C1orf50 ESRRG PPARG TRIM54 TTC23
Entrez ID		64927	196883
HPRD ID		07777	11614
Ensembl ID		ENSG00000103852	ENSG00000129467
Uniprot IDs		Q5W5X9	Q86TZ7 Q8NFM4
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoskeleton Keratin Filament Identical Protein Binding Intermediate Filament Organization Protein Binding Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Asymmetric Cell Division Ubiquitin Protein Ligase Activity Positive Regulation Of Apoptotic Process Response To Herbicide Protein Serine/threonine Kinase Binding Transcription Coactivator Activity MRF Binding Positive Regulation Of Programmed Cell Death	Retinoic Acid Receptor Signaling Pathway Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion AF-2 Domain Binding Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of Lipoprotein Transport Arachidonate Binding Negative Regulation Of Mitochondrial Fission Negative Regulation Of Type II Interferon-mediated Signaling Pathway LBD Domain Binding Prostaglandin Receptor Activity DNA Binding Domain Binding Estrogen Response Element Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Extracellular Matrix Assembly STAT Family Protein Binding Regulation Of Connective Tissue Replacement Alpha-actinin Binding
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