PPL and HECTD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPL	HECTD3
Description		periplakin	HECT domain E3 ubiquitin protein ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Syntaxin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	17 interacting genes: BRCA1 CASP8 CASP9 CHUK HSP90AA1 PARP1 PPL RAF1 TP53 TRIOBP UBE2A UBE2C UBE2D2 UBE2D3 UBE2Q2 UBE2S ZDHHC17
Entrez ID		5493	79654
HPRD ID		04187	13383
Ensembl ID		ENSG00000118898	ENSG00000126107
Uniprot IDs		O60437	A1A4G1 B3KU34 Q5T447
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?		Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Transferase Activity Macromolecule Metabolic Process Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Protein Ubiquitination Positive Regulation Of Execution Phase Of Apoptosis Protein K6-linked Ubiquitination ATP Binding Protein Modification By Small Protein Conjugation Protein-containing Complex Regulation Of Programmed Necrotic Cell Death Proteolysis Glial Cell Apoptotic Process Apoptotic Process Apoptotic Signaling Pathway Nucleotide Binding Response To Indole-3-methanol Response To Anesthetic Positive Regulation Of Ubiquitin Protein Ligase Activity Response To UV Programmed Cell Death Cell Death Mitochondrial DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Free Ubiquitin Chain Polymerization Cellular Response To Radiation Cytosol Response To Stress Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Cobalt Ion Protein Autoubiquitination Scaffold Protein Binding DNA Metabolic Process Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response
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