PPL and UPRT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPL	UPRT
Description		periplakin	uracil phosphoribosyltransferase homolog
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Nucleotide Binding Protein Binding GTP Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	UMP Biosynthetic Process Female Pregnancy Lactation Response To Insulin
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	9 interacting genes: COMMD1 ERH GGA3 HSF2BP KAT5 NPM3 POLR2G PPL PYROXD1
Entrez ID		5493	139596
HPRD ID		04187	06640
Ensembl ID		ENSG00000118898	ENSG00000094841
Uniprot IDs		O60437	A0A0A0MRR5 E9PSD7 Q96BW1
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?		Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether	Positive Regulation Of Protein Metabolic Process Histone H2AK5 Acetyltransferase Activity Protein Targeting To Vacuole Nucleotide-excision Repair Establishment Of Protein Localization To Vacuole Protein Destabilization Protein Localization To Cell Surface Golgi To Plasma Membrane Transport Positive Regulation Of Cholesterol Import Nucleobase-containing Compound Metabolic Process Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Protein Localization To Vacuole Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway DNA-templated Transcription Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Endosome To Plasma Membrane Protein Transport Nucleic Acid Metabolic Process Piccolo Histone Acetyltransferase Complex DNA Repair Vesicle-mediated Transport To The Plasma Membrane Regulation Of Plasma Lipoprotein Particle Levels
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