PPL and ACTR5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPL	ACTR5
Description		periplakin	actin related protein 5
Image
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Ino80 Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Telomere Maintenance DNA Metabolic Process Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Strand Elongation UV-damage Excision Repair Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Femur bone mineral density x serum urate levels interaction ( 34046847) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Schizophrenia ( 25056061 29483656)
Interacting Genes		44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	2 interacting genes: CSNK2B PPL
Entrez ID		5493	79913
HPRD ID		04187	08575
Ensembl ID		ENSG00000118898	ENSG00000101442
Uniprot IDs		O60437	Q9H9F9
PDB IDs		4Q28	6HTS 7ZI4
Enriched GO Terms of Interacting Partners?		Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether	Positive Regulation Of Activin Receptor Signaling Pathway Protein Kinase CK2 Complex Negative Regulation Of Viral Life Cycle Symbiont-mediated Disruption Of Host Cell PML Body Release From Viral Latency Adiponectin-activated Signaling Pathway Endothelial Tube Morphogenesis Protein Kinase Regulator Activity Peptidyl-threonine Phosphorylation PcG Protein Complex Regulation Of Activin Receptor Signaling Pathway Desmosome Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Cornified Envelope Wound Healing Keratinization
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