PPL and C6orf141

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPL	C6orf141
Description		periplakin	chromosome 6 open reading frame 141
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Protein Binding
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	3 interacting genes: CRK EPS8 PPL
Entrez ID		5493	135398
HPRD ID		04187	12852
Ensembl ID		ENSG00000118898	ENSG00000197261
Uniprot IDs		O60437	Q5SZD1
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?		Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether	Helper T Cell Diapedesis Mononuclear Cell Migration Cytoskeleton Organization Regulation Of Cell Shape Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Leukocyte Migration Cerebellar Neuron Development Regulation Of Cell Morphogenesis Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Actin Filament-based Process Regulation Of Small GTPase Mediated Signal Transduction Diapedesis Extracellular Exosome Actin Cytoskeleton Organization Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Endothelin Cellular Response To Endothelin Postsynaptic Specialization Assembly Actin Polymerization-dependent Cell Motility NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol Stereocilium Bundle Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Response To Hepatocyte Growth Factor Cellular Response To Nitric Oxide Regulation Of Cytoskeleton Organization Insulin-like Growth Factor Receptor Binding Response To Yeast Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Stereocilium Tip Exit From Mitosis Regulation Of Receptor Clustering Cellular Response To Reactive Nitrogen Species Organelle Organization Response To Peptide Positive Regulation Of Rac Protein Signal Transduction Barbed-end Actin Filament Capping Response To Nitric Oxide Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization Regulation Of Cell Projection Organization Dendritic Cell Migration Rac Protein Signal Transduction
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